脂肪移植研究现状及发展趋势文献计量学和可视化分析

Research status and development trends in fat transplantation:bibliometrics and visual analysis

目的应用文献计量学方法研究近10年来国际上脂肪移植相关文献, 并进行可视化分析, 探讨该领域的研究现状、热点及发展趋势。方法通过Web of Science数据库核心合集检索2011至2020年间与脂肪移植研究相关的文献, 并严格按照纳入标准和排除标准筛选文献。对纳入文献通过文献计量学的方法对年份、出版期刊、第一作者、国家和机构发文量及学科分布进行统计分析。应用CiteSpace 5.7.R5W软件对纳入文献进行共被引分析, 并对文献的关键词进行共现分析和突现词分析;应用VOSviewer 1.6.16软件对纳入文献的文题和摘要中的术语进行可视化聚类, 以揭示热点话题和研究前沿。结果共纳入文献4 901篇, 2011至2020年间年度发文量持续增加。研究期间发文量排名前3位的期刊分别是Plastic and Reconstructive Surgery(320篇)、Aesthetic Surgery Journal(171篇)、PLoS One(113篇);排名前3位的第一作者分别是Rafael Denadai(13篇)、Gentile Pietro(12篇)、Khouri Roger(6篇);排名前3位的国家分别是美国(1 646篇)、中国(853篇)、意大利(383篇);排名前3位的机构分别是匹兹堡大学(96篇)、上海交通大学(78篇)、米兰大学(63篇)。脂肪移植相关文献共涉及87个研究领域, 其中涉及最多的领域是外科手术。CiteSpace 5.7.R5W软件可视化分析显示, 4 901篇文献共建立了一个由381个节点、608根连线、12个聚类所组成的文献共被引网络;文献中共有69 599个关键词, 排名前5位的关键词涉及文献数量从高到低依次为"transplantation(移植)"、"adipose tissue(脂肪组织)"、"stem-cell(干细胞)"、"tissue(组织)"、"obesity(肥胖)";文献中突现强度最大的关键词是"outcome(结果)", 突现时间最长的是"cartilage(软骨)", 最近几年突现的5个关键词是"liver disease(肝脏疾病)"、"trial(试验)"、"stromal vascular fraction(血管基质成分)"、"outcome(结果)"、"Akkermansia muciniphila(嗜黏蛋白阿克曼菌)"。VOSviewer 1.6.16软件可视化聚类结果显示, 脂肪移植在整形美容手术中的应用、脂肪组织来源及其在体内的存活机制、关于脂肪再生的实验室研究是目前脂肪移植技术领域的三大热点。结论国际上关于脂肪移植的研究呈现上升趋势, 国内外的研究机构都在对脂肪移植进行深入探索, 近期研究热点侧重于提高脂肪移植物远期存活率, 研究层面逐渐深入到分子水平。

Objective Using bibliometrics to study the international literature on fat transplantation in recent 10 years,and to explore the research status,hot spots and development trend in this field.Methods Literatures related to fat transplantation research from 2011 to 2020 were searched through the core collection of Web of Science database,and the literatures were screened strictly according to inclusion and exclusion criteria.Statistical analysis was conducted on the year,journal,first author,number of articles published by countries and institutions,and distribution of disciplines by bibliometrics.Citespace5.7.R5W software was used for co-citation analysis of the included literatures.Cooccurrence analysis and emergent word analysis were also carried out on the keywords in the literature.VOSviewer1.6.16 software was used to perform visual clustering of terms in the title and abstract of the included literature to reveal hot topics and research frontiers.Results A total of 4901 papers were included,and the number of annual publications continued to increase from 2011 to 2020.The top three publications during the study period were Plastic and Reconstructive Surgery(320 papers),Aesthetic Surgery Journal(171 papers),and PLoS One(113 papers).The first authors were Rafael Denadai(13 papers),Gentile Pietro(12 papers),Khouri Roger(6 papers).The most productive countries and institutions in this field were the United States(1646 papers),China(853 papers),and Italy(383 papers).The organizations with the largest number of publications were the University of Pittsburgh(96 papers),Shanghai Jiao Tong University(78 papers),and Milan University(63 papers).There were 87 research categories in the literature related to fat transplantation,of which surgery was involved mostly.Visual analysis of Cites Pace5.7.R5W software showed that 4901 references had established a co-citation network consisting of 381 nodes,608 links and 12 clusters.There were 69599 keywords in the literature,and the top five keywords from high to low were"transplantation""adipose tissue""stem-cell""tissue",and"obesity".In the literature,the keywords with the highest intensity of outburst was"outcome",and the keywords with the longest duration of outburst was"cartilage".In recent years,the five keywords with outburst were"liver disease""trial""stromal vascular fraction""outcome",and"Akkermansia muciniphila".VOSviewer1.6.16 software visualization clustering result showed that the application of fat transplantation in plastic surgery,the source of adipose tissue and its survival mechanism in vivo,and the laboratory research on fat regeneration were the three hot spots in the field of fat transplantation technology.Conclusions The research on fat transplantation is on the rise in the world,and research institutions at home and abroad are conducting in-depth exploration on fat transplantation.Recent research focuses on improving the long-term survival rate of fat transplantation,and the research level is gradually in-depth at the molecular level.