摘要
听力损失是目前最普遍的慢性发展性疾病之一。大多研究表明听力损失的发生发展与氧化应激造成的氧化损伤密切相关,而还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶(NADPH oxidase,NOX)是机体活性氧生成的主要酶类之一,由7种亚型(NOX1、NOX2、NOX3、NOX4、NOX5、DUOX1、DUOX2)组成。为了探讨听力损失与氧化应激的关系,现就NOX介导氧化应激与听力损失病理机制的最新研究进展予以综述。
Hearing loss is one of the most common chronic developmental diseases.The available studies have demonstrated that the occurrence and development of hearing loss is closely related to oxidative damage caused by oxidative stress.Nicotinamide adenine dinucleotide phosphate oxidase(NADPH oxidase,NOX)contribute to the production of reactive oxygen and are classified into seven subtypes(NOX1,NOX2,NOX3,NOX4,NOX5,DUOX1,and DUOX2).To explore the relationship between oxidative stress and hearing loss,this paper reviews the latest research progress in the pathological mechanism of NOX-mediated oxidative stress and hearing loss.
作者
何蒙娇
谌容
汪海燕
桂飞
宋丹丹
杨磊
HE Mengjiao;SHEN Rong;WANG Haiyan;GUI Fei;SONG Dandan;YANG Lei(School of Public Health,Hangzhou Normal University Division of Health Sciences,Hangzhou 311121,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2022年第3期510-515,共6页
Acta Academiae Medicinae Sinicae
基金
浙江省自然科学基金(LY18H260002)
杭州市重大科技创新项目(20152013A01)。
