重型颅脑损伤患者血清细胞粘合素C浓度检测的临床价值

Clinical value of determination of serum tenascin-C concentrations in patients with severe traumatic brain injury

目的研究血清细胞粘合素C浓度对重型颅脑损伤(sTBI)患者住院期间死亡、外伤性脑梗死、急性创伤性凝血病、急性肺损伤和进展性出血性脑损伤等不良事件的预测价值。方法选取102例sTBI患者,检测患者入院时血清细胞粘合素C浓度,采用格拉斯哥昏迷(GCS)评分和鹿特丹CT评分评估伤情程度,统计分析血清细胞粘合素C浓度对sTBI患者住院期间不良事件的预测价值。结果血清细胞粘合素C浓度与sTBI患者入院时GCS评分和鹿特丹CT评分显著相关(均P<0.01),是sTBI患者住院期间不良事件的独立预测因素(均P<0.05),预测能力与入院时GCS评分和鹿特丹CT评分比较,差异均未有统计学意义(均P>0.05)。结论sTBI患者血清细胞粘合素C浓度与伤情程度及临床预后密切相关,提示血清细胞粘合素C可能是sTBI潜在的预后标志物。

Objective To investigate the predictive ability of serum tenascin-C concentrations for in-hospital adverse affairs,including mortality,posttraumatic cerebral infarction,acute traumatic coagulopathy,acute lung injury and progressive hemorrhagic injury in patients with severe traumatic brain injury(sTBI).Methods 102 patients with sTBI were enrolled.Serum tenascin-C concentration was measured.Glasgow coma scale(GCS)scores and Rotterdam CT scores were utilized to assess trauma severity.Statistical methods were used to assess the predictive value of serum Tenascin-C concentrations for in-hospital adverse affairs after sTBI.Results Serum tenascin-C concentrations were tightly correlated with GCS scores and Rotterdam CT scores(both P<0.01),and emerged as an independent predictor for in-hospital adverse affairs(all P<0.05)and there were no significant differences in terms of predictive capabilities between serum tenascin-C concentrations and GCS scores in addition to Rotterdam CT scores(all P>0.05).Conclusion Serum tenascin-C concentrations after sTBI are intimately correlated with trauma severity and clinical outcome,indicating serum tenascin-C may be a potential prognostic biomarker of sTBI.