孕烷X受体在心血管疾病中的作用机制及中药调控研究进展

Mechanism of Pregnane X Receptor in Cardiovascular Diseases and Regulation of Traditional Chinese Medicine

心血管疾病多由糖脂代谢紊乱与血管内皮损伤引起。作为核受体超家族的一员,孕烷X受体(PXR)在心血管组织中表达并可被多种内外源异物活化,除经典的药物解毒效应,PXR在胰岛素敏感性、糖脂稳态、改善动脉粥样硬化和血管功能等方面有一定作用。现就PXR参与调控动脉粥样硬化、调控血压、减缓心力衰竭进程等心血管疾病的作用分子机制以及中药激活PXR在心血管疾病治疗的机制做简单介绍,以期为今后的研究提供参考。

Cardiovascular diseases are mostly caused by glycolipid metabolism disorders and vascular endothelial damage.As a member of the nuclear receptor superfamily,pregnane X receptor(PXR)is expressed in cardiovascular tissues and activated by a variety of xenobiotics and endobiotics,in addition to its conventional function in drug detoxification,PXR also plays a role in insulin sensitivity,glycolid and lipid homeostasis,improvement of atherosclerosis and vascular function.In this review,we discuss the differential role of PXR in the atherosclerosis,blood pressure and heart failure,and the mechanism of traditional Chinese medicine activating PXR in the treatment of cardiovascular diseases,so as to provide reference for future studies.