阿立哌唑联合氨磺必利治疗首发精神分裂症的临床效果

Clinical effect of aripiprazole combined with amisulpride in the treatment of first-episode schizophrenia

目的观察阿立哌唑联合氨磺必利治疗首发精神分裂症的临床效果。方法回顾性选取2019年9月—2021年3月广东省惠州市第二人民医院收治的首发精神分裂症患者60例,根据治疗方法不同分为观察组和对照组,每组30例。2组患者均接受常规治疗,在此基础上,对照组采用氨磺必利治疗,观察组采用阿立哌唑联合氨磺必利治疗,1周为1个疗程,2组均治疗8个疗程。比较2组患者临床疗效、治疗前后阳性和阴性症状量表(PANSS)评分、血清催乳素(PRL)、瘦素水平及不良反应。结果观察组患者总有效率为93.33%,高于对照组的70.00%(χ^(2)=4.630,P=0.031);治疗后,2组患者阳性症状、阴性症状、一般精神药理、总评分均低于治疗前,且观察组低于对照组(P<0.05);治疗后,2组患者PRL水平均低于治疗前,且观察组低于对照组(P<0.01);观察组患者治疗前后瘦素水平比较差异无统计学意义(P>0.05),对照组患者治疗后瘦素水平高于治疗前及观察组(P<0.01);2组患者不良反应总发生率比较差异无统计学意义(χ^(2)=0.131,P=0.718)。结论阿立哌唑联合氨磺必利治疗首发精神分裂症可获得更满意的效果,降低患者血清PRL水平,且安全性良好,值得临床推广与应用。

Objective To observe the clinical effect of aripiprazole combined with amisulpride in the treatment of first-episode schizophrenia.Methods A total of 60 patients with first-episode schizophrenia who were admitted to Huizhou Second People’s Hospital,Guangdong Province from September 2019 to March 2021 were retrospectively selected,and they were divided into observation group and control group according to different treatment methods,with 30 cases in each group.Both groups received conventional treatment,on this basis,the control group was treated with amisulpride,and the observation group was treated with aripiprazole combined with amisulpride,one week was a course of treatment,and both groups were treated for 8 courses of treatment.The clinical efficacy,positive and negative symptom scale(PANSS)scores,the levels of serum prolactin(PRL)and leptin and adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of patients in the observation group was 93.33%,which was higher than 70.00% in the control group(χ^(2)=4.630,P=0.031);After treatment,the positive symptoms,negative symptoms,general psychopharmacology and total scores of the two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05);After treatment,the PRL levels in both groups were lower than those before treatment,and the observation group was lower than the control group(P<0.01);There was no significant difference in the leptin level of the observation group before and after treatment(P>0.05),and the leptin level of the control group after treatment was higher than that before treatment and the observation group(P<0.01);There was no significant difference in the total incidence of adverse reactions between the two groups(χ^(2)=0.131,P=0.718).Conclusion Aripiprazole combined with amisulpride in the treatment of first-episode schizophrenia can achieve a more satisfactory effect,can reduce the levels of serum PRL,and has good safety,which is worthy of clinical promotion with application.