拉贝洛尔联合酚妥拉明治疗对妊娠期高血压患者的影响

Effect of Labeolol Combined with Phentolamine on Hypertensive Patients During Pregnancy

目的研究拉贝洛尔联合酚妥拉明治疗对妊娠期高血压患者的影响。方法随机选取2020年1月至2021年7月洛阳市中心医院妊娠期高血压患者160例。依照随机数字分表法,分为对照组、观察组,各80例。两组均给予常规干预,对照组采用酚妥拉明治疗,观察组采用拉贝洛尔联合酚妥拉明治疗。对比两组疗效、治疗前后舒张压(DBP)、收缩压(SBP)、24 h尿蛋白量、血清胎盘生长因子(PLGF)、妊娠相关血浆蛋白A(PAPPA)、全血高切黏度(HBV)、纤维蛋白原(FIB)、全血低切黏度(LBV)、血浆黏度(PV)、不良妊娠结局发生情况。结果观察组有效率95.00%(76/80)高于对照组76.25%(61/80),差异有统计学意义(P<0.05);与对照组相比,治疗后观察组DBP、SBP、24 h尿蛋白均较低,差异有统计学意义(P<0.05);与对照组相比,治疗后观察组PLGF水平较高,PAPPA水平较低,差异有统计学意义(P<0.05);与对照组相比,观察组治疗后HBV、FIB、LBV、PV较低,差异有统计学意义(P<0.05);两组不良妊娠结局发生率比较,观察组5.00%(4/80)低于对照组16.65%(13/80),差异有统计学意义(P<0.05)。结论拉贝洛尔联合酚妥拉明治疗妊娠期高血压疗效显著,可降低患者血压,改善血清PLGF、PAPPA水平,促进血液流变学恢复正常,且安全性高。

Objective To study the effect of labeolol combined with phentolamine on hypertension during pregnancy.Methods A total of 160 patients with gestational hypertension in Luoyang Central Hospital from January 2020 to July 2021 were randomly selected.According to the random number subtable method,they were divided into control group and observation group,80 cases in each group.The control group was treated with phentolamine,and the observation group was treated with labeolol combined with phentolamine.The efficacy,diastolic blood pressure(DBP),systolic blood pressure(SBP),24h urine protein level,serum placental growth factor(PLGF),pregnancy-associated plasma protein A(PAPPA),whole blood high shear viscosity(HBV),fibrinogen(FIB),whole blood low shear viscosity(LBV),plasma viscosity(PV),incidence of adverse pregnancy outcomes before and after treatment were compared between the two groups.Results The effective rate in observation group was 95.00%(76/80)higher than 76.25%(61/80)in control group,and the difference was statistically significant(P<0.05).Compared with the control group,DBP,SBP and 24 h urine protein in the observation group were lower after treatment,and the differences were statistically significant(P<0.05).Compared with the control group,the level of PLGF was higher and PAPPA was lower in the observation group after treatment,with statistical significance(P<0.05).Compared with the control group,HBV,FIB,LBV and PV in the observation group were lower after treatment,and the differences were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 5.00%(4/80)lower than that in the control group(16.65%(13/80),and the difference was statistically significant(P<0.05).Conclusion Labeolol combined with phentolamine has significant efficacy in the treatment of gestational hypertension,which can reduce blood pressure,improve serum PLGF and PAPPA levels,and promote hemorheology to return to normal,and with high safety.