摘要
感染性和炎症性疾病常伴有代谢改变,代谢相关脂肪性肝病(MAFLD)和T2DM特点是具有高水平的促炎细胞因子。补体C1q/TNF相关蛋白(CTRPs)的APN家族因抗炎和Ins增敏作用引起关注。CTRP3、CTRP5、CTRP9、CTRP13可通过调节代谢途径、影响免疫炎症反应控制MAFLD和T2DM的发生发展。本文对CTRP3、CTRP5、CTRP9、CTRP13生物学研究进展进行综述。
Infectious and inflammatory diseases are often accompanied by metabolic changes,such as metabolic fatty liver disease(MAFLD)and type 2 diabetes mellitus(T2DM)characterized by high levels of pro-inflammatory cytokines.In recent years,C1q and tumor necrosis factor related proteins(CTRPs)has aroused widespread interest because of its anti-inflammatory and insulin-sensitizing effects.Many studies have found that CTRP3,CTRP5,CTRP9 and CTRP13 can affect the occurrence and development of MAFLD and T2DM by regulating metabolic pathways and immune inflammatory response.Therefore,this paper reviews the research progress on the expression,regulation and physiological function of CTRP3,CTRP5,CTRP9 and CTRP13.
作者
钱子冰
张琦
曾佩芸
刘静
QIAN Zibing;ZHANG Qi;ZENG Peiyun(The First Clinical Hospital College of Lanzhou University,Lanzhou 730000,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2022年第5期379-382,共4页
Chinese Journal of Diabetes
基金
国家自然科学基金(81760151)。
关键词
C1q/TNF相关蛋白
表达和功能
疾病
C1q/tumor necrosis factor related protein
Expression and function
Disease
