持续皮下泵入胰岛素治疗1型糖尿病研究的进展

Research progress of continuous subcutaneous insulin infusion in treatment of type 1 diabetes mellitus

目前治疗1型糖尿病(T1DM)的最佳方式是“模拟生理胰岛素替代疗法”,包括胰岛素每日多次皮下注射和持续皮下泵入胰岛素(CSII)。CSII可模拟正常机体胰腺的脉冲式分泌模式,持续释放基础胰岛素,可根据患者血糖情况灵活地调整胰岛素的剂量,避免低血糖发生,且其体积较小,便于携带,逐渐被应用于临床中。持续葡萄糖监测(CGM)可动态监测患者血糖,准确反映患者血糖波动情况。本文就CSII联合CGM治疗T1DM研究的进展作一综述。

Current best way to treat type 1 diabetes mellitus(T1DM)is"physiological mimicking insulin replacement therapy",including multiple times daily injections and continuous subcutaneous insulin infusion(CSII).CSII can simulate pulsatile secretion mode of normal body pancreas,continuously release basal insulin,and flexibly adjust insulin dose according to patient's blood glucose situation to avoid hypoglycemia.It is small in size and portable,and is gradually used in clinical practice.Continuous glucose monitoring(CGM)can dynamically monitor blood sugar of patients and accurately reflect the fluctuation of blood sugar in patients.The present article makes a review on research progress of CSII combined CGM in treatment of T1DM.