隆突性皮肤纤维肉瘤30例临床和病理学分析

Clinical and Pathological Analysis of 30 Cases of Dermatofibrosarcoma Protuberans

目的 探讨隆突性皮肤纤维肉瘤(DFSP)的临床病理特点。方法 回顾性分析2011年5月—2020年4月该院诊断的30例DFSP患者的临床表现、组织病理特征、免疫组化特征及术后随访。结果 DFSP患者中,肿瘤组织在真皮及皮下浸润性生长并排列成旋涡状或车轮状,免疫组化检测CD34阳性率96%、Vim阳性率100%,Ki-76阳性率1%~20%,平均9%,S100阴性率为96%。30例患者均接受手术治疗,术后随访5年,13例复发,复发率43.3%。结论 隆突性皮肤纤维肉瘤临床表现多样,了解其临床及病理特征,可提高诊断准确性和提高患者预后。

Objective To investigate the clinicopathological features of dermatofibrosarcoma protuberans(DFSP).MethodsThe clinical manifestations,histopathological characteristics,immunohistochemical characteristics and postoperative follow-up of 30 patients with DFSP diagnosed in the hospital from May 2011 to April 2020 were retrospectively analyzed.ResultsAmong the DFSP patients,the tumor tissue grows infiltratingly in the dermis and subcutaneous tissue and is arranged in a spiral or wheel shape.The positive rate of CD34 by immunohistochemistry is96%,the positive rate of Vim is 100%,the positive rate of Ki-76 is 1%-20%,with an average of 9%,and the S100negative rate was 96%.All 30 patients received surgical treatment and were followed up for 5 years after operation,13 patients recurred,with a recurrence rate of 43.3%.ConclusionThe clinical manifestations of dermatofibrosarcoma protuberans are diverse,and understanding its clinical and pathological features can improve the diagnostic accuracy and improve the prognosis of patients.