CO_(2)点阵激光、他克莫司联合复方甘草酸苷片治疗稳定期非节段型白癜风的效果观察

Effect of CO_(2) dot matrix laser combined with tacrolimus and compound glycyrrhizin tablets on stable non segmental vitiligo

目的探讨CO_(2)点阵激光、他克莫司联合复方甘草酸苷片治疗稳定期非节段型白癜风的临床效果。方法抽取驻马店市第一人民医院2020年3月至2021年3月收治的90例稳定期非节段型白癜风患者,依据随机数字表法分为对照组(45例)和观察组(45例)。对照组给予CO_(2)点阵式激光照射及他克莫司乳膏涂抹治疗,观察组在对照组治疗基础上联合应用复方甘草酸苷片口服。比较两组患者治疗后3、6个月的临床效果,同时记录治疗期间两组不良反应发生情况。结果治疗3个月后,观察组总有效率(55.56%,25/45)与对照组(35.56%,16/45)比较,差异未见统计学意义(P>0.05);治疗6个月后,观察组总有效率(80.00%,36/45)高于对照组(42.22%,19/45),P<0.05。两组不良反应发生率比较,差异未见统计学意义(P>0.05)。结论CO_(2)点阵激光、他克莫司联合复方甘草酸苷片治疗稳定型非节段性白癜风的疗效较好,安全性较高。

Objective To investigate the clinical effects of CO_(2) dot matrix laser combined with tacrolimus and compound glycyrrhizin tablets in the treatment of stable non segmental vitiligo.Methods Ninety patients with stable non segmental vitiligo treated in Zhumadian First People’s Hospital from March 2020 to March 2021 were selected and divided into control group(45 cases)and observation group(45 cases)by random number table method.The control group was treated by CO_(2) dot matrix laser irradiation and tacrolimus cream,and the observation group was treated with compound glycyrrhizin tablets based on the treatment of the control group.The 3-and 6-month postoperative clinical effects of the two groups were compared,and the adverse reactions during the treatment were recorded.Results After 3 months of treatment,there was no significant difference in the total effective rate between the observation group(55.56%,25/45)and the control group(35.56%,16/45),P>0.05.After 6 months of treatment,the total effective rate of the observation group(80.00%,36/45)was higher than that of the control group(42.22%,19/45),P<0.05.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions CO_(2) dot matrix laser combined with tacrolimus and compound glycyrrhizin tablets is effective and safe in the treatment of stable non segmental vitiligo.