多排容积CT双血供灌注参数与肺癌患者临床病理特征的相关性

Correlation between double blood perfusion parameters of multi-slice volume CT and clinicopathological features of lung cancer

目的分析多排容积CT双血供灌注参数与肺癌患者临床病理特征的相关性。方法前瞻性纳入信阳职业技术学院附属医院2018年8月至2020年8月收治的68例肺癌患者,所有患者均行CT诊断,记录CT双血供灌注参数肺动脉流量(PAF)、支气管动脉血流量(BAF)、灌注指数(PI),绘制受试者工作特征曲线并计算曲线下面积(AUC),分析多排容积CT双血供灌注参数对肺癌患者临床病理特征的预测价值。结果不同年龄、性别、肿瘤长径、肿瘤分期、分化程度、肿瘤类型、淋巴结转移、脉管浸润患者PAF值比较,差异未见统计学意义(P>0.05);T3~T4期、淋巴结转移患者BAF值均高于T1~T2期、淋巴结无转移患者,T3~T4期、淋巴结转移患者PI值低于T1~T2期、淋巴结无转移患者(P<0.05);其他不同病理特征患者BAF、PI值比较差异未见统计学意义(P>0.05)。绘制受试者工作特征曲线结果显示,BAF、PI值联合诊断肺癌肿瘤T3~T4期的AUC为0.863(95%CI:0.773~0.953),诊断价值较高;BAF、PI值联合诊断肺癌淋巴结转移的AUC为0.874(95%CI:0.786~0.962),诊断价值较高。结论BAF值升高、PI降低提示肺癌患者肿瘤分期程度高,有淋巴结转移风险。

Objective To analyze the correlation between double blood perfusion parameters of multi-slice volume CT and clinicopathological features of lung cancer.Methods Sixty-eight patients with lung cancer admitted to the Affiliated Hospital of Xinyang Vocational and Technical College from August 2018 to August 2020 were prospectively included.All patients underwent CT diagnosis.Pulmonary artery flow(PAF),bronchial artery flow(BAF)and perfusion index(PI)were recorded.The receiver operating characteristic curve was drawm,and the area under the curve(AUC)was calculated to analyze the value of dual blood supply perfusion parameters of multi-slice volume CT in predicting the clinicopathological characteristics of patients with lung cancer.Results There was no significant difference in PAF value among patients with different ages,genders,tumor diameters,tumor stages,degrees of differentiation,tumor types,lymph node metastasis and vascular invasion(P>0.05).BAF value of patients with T3-T4 stage and lymph node metastasis was higher than that of patients with T1-T2 stage and without lymph node metastasis,PI value of patients with T3-T4 stage and lymph node metastasis was lower than that of patients with T1-T2 stage and without lymph node metastasis(P<0.05);and there was no statistical significance in BAF and PI of patients with other different pathological characteristics(P>0.05).The results of receiver operating characteristic curve showed that the AUC of BAF combined with PI in the diagnosis of T3-T4 stage of lung cancer was 0.863(95%CI:0.773-0.953),which was of high diagnostic value;the AUC of BAF combined with PI in the diagnosis of lymph node metastasis of lung cancer was 0.874(95%CI:0.786-0.962),which was of high diagnostic value.Conclusions The increase of BAF and the decrease of PI suggests high tumor stage of lung cancer and a risk of lymph node metastasis.