经皮冠状动脉介入治疗前早期静脉注射兰地洛尔对ST段抬高型心肌梗死患者心肌挽救的有效性和安全性

Effectiveness and safety of early intravenous injection of landiolol before percutaneous coronary intervention for myocardial rescue in patients with ST-segment elevation myocardial infarction

目的探讨经皮冠状动脉介入治疗前早期静脉注射兰地洛尔对ST段抬高型心肌梗死患者心肌挽救的有效性和安全性。方法抽取2019年3月至2020年3月于山西省心血管病医院接受治疗的200例被诊断为ST段抬高型心肌梗死并具有完整随访记录的患者,依据双盲法分为观察组与对照组,每组100例。观察组静脉注射兰地洛尔,对照组静脉注射生理氯化钠溶液。比较两组心肌挽救指数值及其他磁共振成像数据结果。结果观察组心肌挽救指数为(42.95±7.81)%,高于对照组的(32.75±10.38)%,P<0.05。两组左心室质量、风险心肌质量、梗死心肌质量和左室心肌梗死比例比较差异均未见统计学意义(P均>0.05)。结论经皮冠状动脉介入治疗前早期静脉注射兰地洛尔可能会增加ST段抬高型心肌梗死患者的心肌挽救程度,且不会产生额外的血流动力学不良反应。

Objective To investigate the effectiveness and safety of early intravenous injection of landiolol before percutaneous coronary intervention for myocardial rescue in patients with ST-segment elevation myocardial infarction.Methods Two hundred patients who were diagnosed with ST-segment elevation myocardial infarction and had complete follow-up records treated in Shanxi Cardiovascular Hospital from March 2019 to March 2020 were selected,and they were divided into observation group and control group according to the double-blind method,with 100 cases in each group.The observation group received landiolol by intravenous injection,and the control group received normal saline by intravenous injection.The myocardial rescue index and other magnetic resonance imaging data were compared between the two groups.Results The myocardial rescue index of the observation group was(42.95±7.81)%,higher than the(32.75±10.38)%of the control group(P<0.05).There was no significant difference in left ventricular mass,risk myocardial mass,infarcted myocardial mass and left ventricular myocardial infarction ratio between the two groups(all P>0.05).Conclusions Early intravenous injection of landiolol before percutaneous coronary intervention may increase the degree of myocardial salvage in patients with ST-segment elevation myocardial infarction,without causing additional significant hemodynamic adverse reactions.