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文献报道安罗替尼不良反应分析 被引量:5

Analysis of Adverse Drug Reactions of Anlotinib Reported in Literature
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摘要 目的分析安罗替尼不良反应(ADR)发生情况及临床特点,为临床安全用药提供参考。方法检索PubMed数据库、Web of Science数据库、中国知网数据库、万方数据库和维普中文科技期刊数据库关于安罗替尼ADR的文献并进行分析。结果检索到安罗替尼ADR报道21篇,患者共25例,平均年龄(59.56±11.67)岁,其中男14例(56.00%),女11例(44.00%)。ADR诱发时间主要为用药后2个月内(73.68%),所致ADR以心血管系统损害(28.95%)为主,其次为呼吸系统损害(15.79%)和皮肤及其附件损害(13.16%)。结论临床医师和药师应了解安罗替尼ADR发生特点,用药过程应加强监测,保障患者用药安全。 Objective To analyze the status and clinical characteristics of adverse drug reactions(ADRs)of anlotinib to provide a reference for clinical rational drug use.Methods PubMed,Web of Science,CNKI,Wanfang database and VIP database were searched for ADRs of anlotinib,and the collected literatures were further analyzed statistically.Results A total of 21 articles were included,involving 25 patients.The average age of the patients was(59.56±11.67)years old.Among them,14 cases(56.00%)were male and 11 cases(44.00%)were female.The ADR mainly occurred within two months(73.68%)after therapy.ADRs of anlotinib were mainly cardiovascular system injury(28.95%),and followed by respiratory(15.79%),skin and accessory(13.16%)system injury.Conclusion Clinicians and pharmacists should understand the characteristics of the ADRs of anlotinib.More attention should be paid to ADRs of anlotinib to ensure the safety of drug use.
作者 曹雨晴 张瑞 师莹莹 杜书章 CAO Yuqing;ZHANG Rui;SHI Yingying;DU Shuzhang(Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处 《医药导报》 CAS 北大核心 2022年第7期1052-1055,共4页 Herald of Medicine
基金 白求恩·医学科学研究基金资助项目(B19246AT)。
关键词 安罗替尼 药品不良反应 文献分析 Anlotinib Adverse drug reactions Literature analysis
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