PM_(10)短期暴露对糖尿病发病相关生物标志物的影响

Effects of short-term exposure to PM_(10) on biomarkers of diabetes

为探讨PM_(10)对糖尿病发病相关生物标志物的效应,以“金昌队列”为平台,采用随机抽样方法在基线人群中选择2型糖尿病、糖尿病前期和血糖正常组共420人,用近邻模型完成个体PM_(10)暴露评估。运用酶联免疫吸附法对炎症反应指标(IL-6、VCAM-1)、氧化损伤指标(8-iso-PGF2α)、胰岛功能指标(INS)进行检测,运用多重线性回归模型从以上3方面评价PM_(10)的效应。结果显示:糖尿病前期人群中,滞后6 d时PM_(10)浓度每升高10μg/m^(3),IL-6升高0.45%(95%置信区间(95%CI):0.19%—0.88%),当天的PM_(10)与VCAM-1关联最明显(增幅:1.16%(95%CI:0.43%—2.28%));糖尿病人群中,滞后6 d时PM_(10)与IL-6的关联最显著(增幅:1.52%,(95%CI:0.51%—2.53%)),滞后3 d时8-iso-PGF2α升高2.01%(95%CI:0.29%—3.73%);累积滞后7 d时PM_(10)与HOMA-β关联最明显(降幅:4.63%(95%CI:−8.00%—−1.13%))。文中结果表明大气PM_(10)短期暴露可导致人群出现不同程度的炎症反应、氧化损伤及胰岛β细胞功能障碍。

This study explores the effects of short-term exposure to PM_(10) on related biomarkers of diabetes.Based on the platform of"Jinchang Cohort",a total of 420 patients with type 2 diabetes,pre-diabetes and normal blood glucose are randomly selected.The nearest neighbor model is used to estimate individual exposure levels.IL-6,VCAM-1,8-iso-PGF2αand INS are detected by ELISA.A multiple linear regression model is conducted to evaluate the effects of PM_(10) on the biomarkers.For every 10μg/m^(3) increase in PM_(10) concentration,it is found that IL-6 increases by 0.45%(95%CI:0.19%—0.88%)at lag 6 d,and PM_(10) is most significantly associated with VCAM-1 at lag 0 d(increase:1.16%,95%CI:(0.43%—2.28%))in the prediabetic group.PM_(10) is most significantly associated with IL-6(increase:1.52%,(95%CI:0.51%—2.53%))at lag 6 d,while 8-iso-PGF2αincreases by 2.01%(95%CI:0.29%—3.73%)at lag 3 d,and the relationship between PM_(10) and HOMA-βis most significant at lag 0—7 d(decrease:4.63%,(95%CI:−8.00%—−1.13%))for type 2 diabetes patients.Short-term exposure to PM_(10) can lead to inflammation,oxidative damage and isletβcell dysfunction.