酪酸梭菌肠球菌三联活菌片联合雷贝拉唑三联疗法对老年功能性便秘患者肠道菌群及NO、AChE、5-HT、GAS水平的影响

Effects of Clostridium butyricum Enterococcus triple viable tablets combined with rabeprazole triple therapy on intestinal flora and the levels of NO, AChE,5-HT and GAS in elderly patients with functional constipation

目的探讨酪酸梭菌肠球菌三联活菌片联合雷贝拉唑三联疗法对老年功能性便秘患者肠道菌群及一氧化氮(NO)、乙酰胆碱酯酶(AChE)、5-羟色胺(5-HT)、胃泌素(GAS)水平的影响。方法选取2019年8月至2021年8月我科收治的90例老年功能性便秘患者展开研究,以双盲法将其随机分为对照组和观察组,各45例。对照组采用酪酸梭菌肠球菌三联活菌片治疗,观察组在对照组治疗基础上联合雷贝拉唑三联疗法治疗。比较两组的治疗效果。结果观察组的治疗总有效率为97.78%,高于对照组的82.22%,差异具有统计学意义(P<0.05)。治疗后,观察组的乳杆菌、双歧杆菌活菌数多于对照组,肠杆菌、酵母菌活菌数少于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的NO、5-HT水平低于对照组,AChE、GAS水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组左半结肠、右半结肠、乙状结肠直肠、全结肠传输时间均短于对照组,差异具有统计学意义(P<0.05)。观察组不良反应总发生率略低于对照组,但组间比较,差异无统计学意义(P>0.05)。结论酪酸梭菌肠球菌三联活菌片联合雷贝拉唑三联疗法治疗老年功能性便秘患者有助于提高治疗效果,促进患者肠道菌群改善,也能调节NO、AChE、5-HT、GAS水平,促进肠道功能恢复,值得推广。

Objective To investigate the effect of Clostridium butyricum Enterococcus triple viable tablets combined with rabeprazole triple therapy on intestinal flora and the levels of nitric oxide( NO), acetylcholinesterase( AChE),5-hydroxytryptamine(5-HT) and gastrin(GAS) in elderly patients with functional constipation. Methods A total of 90elderly patients with functional constipation treated in our department from August 2019 to August 2021 were selected for study and randomly divided into control group and observation group by double-blind method, with 45 cases in each group.The control group was treated with Clostridium butyricum Enterococcus triple viable tablets, and the observation group was treated with rabeprazole triple therapy on the basis of the control group. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the observation group was 97.78%, which was higher than82.22% in the control group, and the difference was statistically significant(P<0.05). After treatment, the viable count of Lactobacillus and Bifidobacterium in the observation group were more than those in the control group, the viable count of Enterobacter and Saccharomycetes in the observation group were less than those in the control group, and the differences were statistically significant(P<0.05). After treatment, the levels of NO and 5-HT in the observation group were lower than those in the control group, the levels of AChE and GAS were higher than those in the control group, and the differences were statistically significant(P <0.05). After treatment, the transit time of the left colon, right colon, sigmoid colon and total colon in the observation group were shorter than those in the control group, and the differences were statistically significant(P<0.05). The total incidence of adverse reactions in the observation group was slightly lower than that in the control group, but there was no significant difference between the groups(P >0.05). Conclusion Clostridium butyricum Enterococcus triple viable tablets combined with rabeprazole triple therapy in the treatment of elderly patients with functional constipation can help to improve the treatment effect, promote the improvement of intestinal flora, regulate the levels of NO, AChE, 5-HT and GAS, and promote the recovery of intestinal function, which is worth popularizing.