消瘀定痛散治疗膝关节骨性关节病合并软骨下骨髓水肿

Clinical Study of Xiaoyu Dingtong Powder in Treatment of Knee Osteoarthropathy Complicated with Subchondral Bone Marrow Edema

目的:观察消瘀定痛散外敷治疗膝关节骨性关节病合并软骨下骨髓水肿的临床疗效。方法:50例膝关节骨性关节病合并软骨下骨髓水肿患者随机分为观察组和对照组各25例。观察组给予消瘀定痛散外敷,对照组给予氟比洛芬凝胶贴膏。两组均治疗4周,治疗后比较两组患者临床疗效、视觉模拟量表(visual analogue scale,VAS)评分、西安大略和麦克马斯特大学骨关节炎指数(western ontario and McMaster university osteoarthritis index,WOMAC)评分及膝关节骨髓水肿(WORMS)评分。结果:治疗后,两组患者VAS评分均显著降低(P<0.05);观察组治疗结束及随访4周时VAS评分均显著低于同期对照组(P<0.05)。治疗后,两组患者WOMAC评分、WORMS评分均显著降低(P<0.05);观察组治疗结束及随访4周时WOMAC评分、WORMS评分均低于同期对照组(P<0.05)。结论:消瘀定痛散外敷治疗膝关节骨性关节病合并软骨下骨髓水肿临床疗效显著,能明显减轻患者疼痛、骨髓水肿,改善关节功能。

Objective:To observe the clinical effect of external application of Xiaoyu Dingtong Powder in the treatment of knee osteoarthropathy complicated with subchondral bone marrow edema.Methods:Fifty patients with knee osteoarthropathy complicated with subchondral bone marrow edema were randomly divided into the observation group and the control group,with 25 cases in each.The observation group was given Xiaoyu Dingtong powder for external application,and the control group was given flurbiprofen gel plaster.Both groups were treated for 4 weeks.After treatment,the clinical efficacy,visual analogue scale(VAS) score,western ontario and McMaster university osteoarthritis index(WOMAC) score,and knee bone marrow edema(WORMS) score were compared between the two groups.Results:After treatment,the VAS scores of the two groups were significantly decreased(P<0.05).The VAS scores of the observation group were significantly lower than those of the control group at the end of treatment and 4 weeks of follow-up(P<0.05).After treatment,the WOMAC score and WORMS score of the two groups were significantly decreased(P<0.05).The WOMAC score and WORMS score of the observation group were lower than those of the control group at the end of treatment and 4 weeks of follow-up(P<0.05).The effective rate was 84.00% in the observation group and 72.00% in the control group,and the difference was statistically significant(P<0.05).Conclusion:External application of Xiaoyu Dingtong Powder in treatment of knee osteoarthropathy with subchondral bone marrow edema has a significant clinical effect,which can significantly reduce pain,bone marrow edema,and improve joint function.