阿卡波糖联合二甲双胍对2型糖尿病患者血糖水平的改善情况及BMI指标影响

Acarbose Combined with Metformin Improves Blood Glucose Level and BMI in Patients with Type 2 Diabetes Mellitus

目的探究分析2型糖尿病患者于治疗期间联合应用阿卡波糖、二甲双胍对于血糖水平以及BMI指标的改善效果。方法筛选该院于2020年12月—2021年12月收治的60例2型糖尿病患者作为研究对象展开随机对照研究,以随机数表为分组方式,将收治患者划分为对照组和观察组,每组30例。对照组采用二甲双胍治疗,观察组采用二甲双胍联合阿卡波糖治疗,对比两组患者治疗效果,评估指标包含临床疗效、血糖水平、BMI指标、不良反应发生率。结果观察组临床治疗有效率优于对照组,差异有统计学意义(P<0.05);治疗前,对比两组患者血糖指标,差异无统计学意义(P>0.05),治疗后,观察组血糖指标数值均较对照组低,差异有统计学意义(P<0.05);治疗前,两组患者BMI指数对比,差异无统计学意义(P>0.05),治疗后,观察组BMI指数低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率和对照组比较,差异无统计学意义(P>0.05)。结论2型糖尿病应用阿卡波糖、二甲双胍联合治疗可以有效控制血糖水平,具有较高的安全性以及有效性,可以提升整体治疗效果。

Objective To explore and analyze the improvement effect of combined use of acarbose and metformin on blood glucose level and BMI in patients with type 2 diabetes during treatment.Methods Screening 60 patients with type 2 diabetes who were admitted to the hospital from December 2020 to December 2021 as the research objects to carry out a randomized controlled study,using the random number table as the grouping method,the patients were divided into the control group and the observation group,30 cases in each group.The control group was treated with metformin,and the observation group was treated with metformin combined with acarbose.The treatment effect of the patients in the group was compared,and the evaluation indicators included clinical efficacy,blood glucose level,BMI index,and incidence of adverse reactions.Results The clinical treatment effective rate of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in blood glucose indexes between the two groups(P>0.05).After treatment,the blood glucose indexes values were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in BMI index between the two groups(P>0.05).After treatment,the BMI index of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion The combined treatment of type 2 diabetes with acarbose and metformin can effectively control the blood glucose level,has high safety and efficacy,and can improve the overall treatment effect.