小剂量胰岛素治疗儿童糖尿病酮症酸中毒的临床分析

Clinical Analysis of Low-dose Insulin in the Treatment of Children with Diabetic Ketoacidosis

目的分析小剂量胰岛素治疗儿童糖尿病酮症酸中毒(DKA)的临床效果。方法选择2019年1月—2021年12月该院收治的82例DKA患儿为研究对象,均给予胰岛素治疗,根据治疗剂量的不同分为对照组和观察组,各41例,观察两组的治疗效果。结果两组治疗后空腹血糖和糖化血红蛋白水平均低于治疗前水平,二氧化碳结合力水平均高于治疗前,差异有统计学意义(P<0.05);但两组治疗前后3项指标比较,差异无统计学意义(P>0.05)。观察组血糖达标时间和尿酮体转阴时间短于对照组,血糖降低速度慢于对照组,差异有统计学意义(P<0.05)。两组总有效率比较差异无统计学意义(P>0.05)。观察组并发症发生率4.88%低于对照组21.95%,差异有统计学意义(P<0.05)。结论胰岛素在治疗儿童DKA方面疗效显著,其中采用小剂量的胰岛素治疗在保障治疗效果的同时减少低血糖等并发症的发生,安全性更高。

Objective To analyze the clinical effect of low-dose insulin in the treatment of children with diabetic ketoacidosis(DKA).Methods A total of 82 children with DKA who were treated in the hospital from January 2019 to December 2021 were selected as the research objects,and they were all given insulin therapyAccording to the different treatment doses,they were divided into control group and observation group,with 41 cases in each group.The therapeutic effects of the two groups were observed.Results After treatment,the levels of fasting blood glucose and glycosylated hemoglobin in the two groups were lower than those before treatment,and the levels of carbon dioxide binding capacity were higher than those before treatment,and the differences were statistically significant(P<0.05).There was no significant difference in the three indicators between the two groups before and after treatment(P>0.05).The time of blood glucose reaching the standard and the time of urine ketone body turning negative in the observation group were shorter than those in the control group,and the blood glucose lowering rate was slower than that in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total effective rate between the two groups(P>0.05).The incidence of complications in the observation group was 4.88%lower than that in the control group(21.95%),and the difference was statistically significant(P<0.05).Conclusion Insulin has a significant effect in the treatment of children with DKA,and the use of low-dose insulin therapy can ensure the therapeutic effect while reducing the occurrence of complications such as hypoglycemia,and it is safer.