奥拉西坦对急性重型颅脑损伤并创伤性休克患者抢救效果的影响研究

Effect of oxiracetam on the rescue of patients with acute severe craniocerebral injury and traumatic shock

目的:探讨奥拉西坦对急性重型颅脑损伤并创伤性休克患者抢救效果的影响。方法:选取2019年7月—2021年7月本院收治的150例急性重型颅脑损伤并创伤性休克患者为研究对象,采用随机数字法分为对照组(n=75)和观察组(n=75),对照组患者入院后均行常规治疗,观察组患者在此基础上给予奥拉西坦注射液4.0 g,加入250 ml氯化钠注射液中静脉滴注,1次/d,两组均干预14 d。比较两组的疗效及治疗前后记忆力与智力、神经功能、自觉症状和昏迷程度,并比较两组预后及并发症发生率。结果:观察组的治疗总有效率(86.67%)显著高于对照组(60.00%),预后良好率(26.67%)显著高于对照组(9.33%)(P<0.05)。治疗前,两组的美国国立卫生研究院卒中量表(NIHSS)、自觉症状、简易精神状态量表(MMSE)和格拉斯哥昏迷量表(GCS)评分比较,差异无统计学意义(P>0.05);治疗后,两组的NIHSS和自觉症状评分均明显下降,MMSE和GCS评分均明显上升,其中观察组的上升和下降幅度均显著高于对照组(P<0.05)。两组的并发症发生率比较无明显差异(P>0.05)。结论:奥拉西坦对急性重型颅脑损伤并创伤性休克患者抢救效果显著,能改善患者神经功能及昏迷程度,提高患者预后,值得在临床推广。

Objective:To explore the effect of oxiracetam on the rescue of patients with acute severe brain injury and traumatic shock.Methods:150 patients with acute severe craniocerebral injury and traumatic shock treated in our hospital from July 2019 to July 2021 were randomly divided into the control group(n=75)and the observation group(n=75).Patients in the control group received conventional treatment after admission.Based on the control group,patients in the observation group were given oxiracetam intravenously(4.0 g dissolved in 250 ml normal saline)once a day.Both groups intervened for14 days.The curative effect,memory and intelligence,neurological function,conscious symptoms,and coma degree of both groups before and after treatment were compared,and the prognosis and complication rate of the two groups were compared.Results:The total effective rate of the observation group(86.67%)was significantly higher than that of the control group(60.00%),and the good prognosis rate(26.67%)was significantly higher than that of the control group(9.33%)(P<0.05).Before treatment,there was no significant difference in the scores of the National Institutes of Health Stroke Scale(NIHSS),self-conscious symptoms,Mini-Mental State Scale(MMSE),and Glasgow Coma Scale(GCS)between the two groups(P>0.05).After treatment,NIHSS and self-consciousness symptoms of both groups decreased significantly,while MMSE and GCS scores increased significantly.The increase and decrease of the observation group were significantly higher than those of the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:Oxiracetam has a significant rescue effect on patients with acute severe craniocerebral injury and traumatic shock,which can improve the neurological function,coma degree,and prognosis of patients and is worthy of clinical promotion.