曲酸类酪氨酸酶抑制剂研究进展

Research Progress of Kojic Acid Derivatives as Tyrosinase Inhibitors

曲酸是由曲霉属和青霉属等多种真菌发酵而产生的一类有机酸,具有抗细菌、抗真菌、抗氧化和抗酪氨酸酶等多种生物活性。由于曲酸具有突出的抗酪氨酸酶活性,广泛应用于食品、化妆品、医药等领域。国内外学者以其为先导化合物,进行了大量的结构修饰和改造研究。根据曲酸骨架结构修饰和改造的位置进行分类,介绍近年来文献报道具有抗酪氨酸酶活性的曲酸衍生物,以期为后续研发低毒、高效的新型曲酸类酪氨酸酶抑制剂提供参考。

Kojic acids are a kind of organic acids produced by the fermentation of Aspergillus and Penicillium,which displayed a variety of biological activities such as antibacterial,antifungal,antioxidant,and anti-tyrosinase.Kojic acids have been widely used in food,cosmetics,medicine,and other fields due to their outstanding anti-tyrosinase activity.Various structural modification and transformation studies have been conducted with kojic acids as the lead compounds in domestic and oversea.To provide a reference for the subsequent development of new kojic acid derivatives as tyrosinase inhibitors with low toxicity and high efficiency,this paper reviewed kojic acid derivatives with tyrosinase inhibition activity reported in the literature in recent years and classified these derivatives according to the modified position of the kojic acid skeleton.