基于数据挖掘探讨邹忆怀治疗失眠用药规律

Administration Rule of ZOU Yihuai in Treating Insomnia Based on Data Mining

目的:运用数据挖掘技术分析邹忆怀教授治疗失眠的用药及配伍规律,探讨邹忆怀教授诊治失眠的学术思想与特色。方法:收集2019年1月—2021年6月邹忆怀教授于北京中医药大学东直门医院出诊的处方,利用中医传承辅助系统V2.5,通过频数分析、关联规则、复杂熵聚类分析等数据挖掘方法对筛选出的方剂进行分析。结果:共收集处方131首,涉及中药90味,其中以寒、温药性为主,辛、甘、苦药味占比较大,归经多入心、肝经,使用频数排名前5位的药物是茯苓、柏子仁、菊花、陈皮、佛手,使用频数最高的药物组合依次为柏子仁-茯苓、菊花-茯苓、柏子仁-菊花、陈皮-茯苓、陈皮-柏子仁,挖掘出核心药物组合共14个,并演化得到新处方7首。结论:邹忆怀教授基于“神主睡眠”理论,以“调神安眠”为核心治法,分别以调气畅神、清热安神、养血宁神、镇心敛神之法治疗神滞、神躁、神消、神散四种“神不安”状态,用药精准,平调阴阳,恢复昼夜节律。

Objective:To analyze the administration rule and compatibility law of Prof.ZOU Yihuai in treating insomnia by using data mining technology,and to explore his academic thoughts and characteristics in the treatment of insomnia.Methods:The prescriptions of Prof.ZOU Yihuai,who works in Dongzhimen Hospital of Beijing University of Chinese Medicine,from January 2019 to June 2021 were collected,and the selected prescriptions were analyzed by frequency analysis,association rules,complex entropy clustering analysis and other data mining methods via Chinese Medicine Inheritance Assistant System V2.5.Results:A total of 131 prescriptions were collected,involving 90 kinds of Chinese herbs.Among them,cold and warm herbs accounted for the majority in terms of natures,and acrid,sweet and bitter herbs accounted for a large proportion in terms of flavors;the herbs mainly entered into the heart and liver channels.The top five herbs in use frequency were Poria,Semen Platycladi,FlosChrysanthemi,PericarpiumCitriReticulatae and FructusCitriSarcodactylis.The most frequently used herbal combinations were Semen Platycladi-Poria,FlosChrysanthemiPoria,Semen Platycladi-FlosChrysanthemi,PericarpiumCitriReticulatae-Poria and PericarpiumCitriReticulatae-Semen Platycladi.A total of 14 core herbal combinations were excavated,and seven new prescriptions were developed and obtained.Conclusion:Based on the theory of“the mind governs the sleep”and by taking the core treatment method of“harmonizing the mind and calming the sleep”,Prof.ZOU Yihuai uses the methods of regulating qi and elevating the mind,clearing heat and calming the mind,nourishing the blood and tranquilizing the mind,and tranquilizing the heart and calming the mind to treat the four states of"restless mind"-stagnated mind,agitated mind,negative mind and dissipated mind.He administers the medicine with precision,balances yin and yang,and restores circadian rhythm.