桃红四物汤联合常规西药治疗冠心病心绞痛疗效观察及对血清炎症因子的影响

Clinical Effect of Taohong Siwu Tang Combined with Routine Western Medicine for Coronary Heart Disease Angina Pectoris and Its Effect on Serum Inflammatory Factors

目的:观察桃红四物汤联合常规西药治疗冠心病心绞痛的临床疗效及其对血清炎症因子的影响。方法:选取80例冠心病心绞痛患者为研究对象,按照随机数字表法分为观察组与对照组各40例。对照组采用常规西药治疗,观察组在对照组的基础上加用桃红四物汤治疗。治疗2周后,比较2组临床疗效,2组治疗前后心绞痛发作次数、发作持续时间、血液流变学指标[全血黏度(WBV)、血浆黏度(PV)、纤维原蛋白(Fib)]及血清炎症因子[C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平。结果:观察组总有效率为95.00%,对照组为77.50%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组心绞痛发作次数、持续时间均少于治疗前,且观察组心绞痛发作次数、持续时间均少于对照组,差异均有统计学意义(P<0.05)。治疗后,2组WBV、PV、Fib水平均较治疗前降低,且观察组各项指标均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清炎症因子CRP、TNF-α、IL-6水平均较治疗前降低,且观察组各项指标均低于对照组,差异均有统计学意义(P<0.05)。结论:桃红四物汤联合常规西药治疗冠心病心绞痛,可有效缓解患者临床症状,改善其血液流变学指标,下调血清炎症因子水平。

Objective:To observe the clinical effect of Taohong Siwu tang combined with routine western medicine for coronary heart disease angina pectoris and its effect on serum inflammatory factors.Methods:A total of 80 cases of patients with coronary heart disease angina pectoris were selected as research objects and divided into the observation group and the control group according to the random number table method,with 40 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with aohong Siwu tang based on the treatment of the control group.After two weeks of treatment,the clinical effects in the two groups were compared.Before and after treatment,the changes in frequency and duration of angina pectoris attack,hemorheology indexes including whole blood viscosity(WBV),plasma viscosity(PV)and fibrinogen(Fib)as well as the levels of serum inflammatory factors including C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the two groups were compared.Results:The total effective rate was 95.00%in the observation group and 77.50%in the control group,the difference being significant(P<0.05).After treatment,the frequency and duration of angina pectoris attack in the two groups were less or shorter than those before treatment,and the frequency and duration of angina pectoris in the observation group were less or shorter than those in the control group,differences being significant(P<0.05).After treatment,the levels of WBV,PV and Fib in the two groups were decreased when compared with those before treatment,and all the above indexes in the observation group were lower than those in the control group,differences being significant(P<0.05).After treatment,the levels of serum inflammatory factors including CRP,TNF-αand IL-6 in the two groups were decreased when compared with those before treatment,and all the above indexes in the observation group were lower than those in the control group,differences being significant(P<0.05).Conclusion:The therapy of Taohong Siwu tang combined with routine western medicine for coronary heart disease angina pectoris can effectively relieve the clinical symptoms of patients,improve their hemorheology indexes,and down-regulate the levels of serum inflammatory factors.