解郁汤加味联合阿立哌唑治疗精神分裂症疗效观察及对炎症因子的影响

Curative Observation on Modified Jieyu Tang Combined with Aripiprazole for Schizophrenia and Its Effect on Inflammatory Factors

目的:观察解郁汤加味联合阿立哌唑治疗精神分裂症的临床效果及其对血清炎症因子水平的影响。方法:选择精神分裂症患者124例,按随机数字表法分为对照组和治疗组各62例。对照组采用阿立哌唑治疗,治疗组在对照组的基础上联合解郁汤加味治疗。治疗4周后评估临床疗效,并进行6个月随访。比较2组总有效率、证候积分、炎症因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-12(IL-12)、肿瘤坏死因子-α(TNF-α)]水平、不良反应及复发率。结果:治疗组总有效率为96.77%,对照组为74.19%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组证候积分比较,差异无统计学意义(P>0.05);治疗后,2组精神抑郁、表情淡漠、语无伦次、胸闷太息及舌红无苔积分均低于治疗前(P<0.05),且治疗组上述各证候积分均低于对照组(P<0.05)。治疗前,2组血清IL-1β、IL-6、IL-12、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,2组上述各炎症因子水平均低于治疗前(P<0.05);且治疗组上述指标均低于对照组(P<0.05)。治疗期间,治疗组不良反应发生率为3.23%,对照组为6.45%,2组比较,差异无统计学意义(P>0.05)。随访6个月,治疗组复发率为1.61%,对照组为11.29%,2组比较,差异有统计学意义(P<0.05)。结论:解郁汤加味联合阿立哌唑能提高精神分裂症患者近期疗效,改善证候积分及炎症因子水平,并可获得较好的远期疗效,且不增加不良反应发生率。

Objective:To observe the clinical effect of modified Jieyu tang combined with aripiprazole for schizophrenia and its effect on serum inflammatory factors.Methods:A total of 124 cases of patients with schizophrenia were selected and divided into the control group and the treatment group according to the random number table method,with 62 cases in each group.The control group was treated with aripiprazole,and the treatment group was additionally treated with modified Jieyu tang based on the treatment of the control group.After four-week treatment,clinical effects were evaluated,and a sixmonth follow-up was carried out.The total effective rates,syndrome scores,levels of inflammatory factors[interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-12(IL-12),and tumor necrosis factor-α(TNF-α)],adverse reactions and recurrence rates were compared between the two groups.Results:The total effective rate was 96.77%in the treatment group and74.19%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of syndrome scores between the two groups(P>0.05).After treatment,scores of mental depression,apathy,incoherent speech,chest oppression and sighing,red tongue without tongue fur in the two groups were lower than those before treatment(P<0.05),and the above syndrome scores in the treatment group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of IL-1β,IL-6,IL-12 and TNF-αbetween the two groups(P>0.05);after treatment,levels of above inflammatory factors in the two groups were lower than those before treatment(P<0.05),and the above indexes in the treatment group were lower than those in the control group(P<0.05).During treatment,the incidence of adverse reactions was 3.23%in the treatment group and 6.45%in the control group,there was no significant difference being found in the comparison(P>0.05).During six-month follow-up,the recurrence rate was 1.61%in the treatment group and 11.29%in the control group,the difference being significant(P<0.05).Conclusion:Modified Jieyu tang combined with aripiprazole can enhance the shortterm curative effect of patients with schizophrenia,reduce syndrome scores and inflammatory factors levels,and achieve a good long-term curative effect,without the increase of incidence of adverse reactions.