小儿消食颗粒联合手法推拿治疗小儿脾胃虚弱型功能性消化不良临床研究

Nursing Study on Xiao’er Xiaoshi Granules Combined with Tuina with Manipulation for Children with Functional Dyspepsia of Spleen Stomach Weakness Type

目的:观察小儿消食颗粒联合手法推拿治疗小儿脾胃虚弱型功能性消化不良的临床疗效。方法:以160例脾胃虚弱型功能性消化不良患儿为研究对象,按照随机数字表法分为对照组和研究组,每组80例。对照组给予双歧杆菌四联活菌片口服治疗,研究组以小儿消食颗粒口服联合手法推拿治疗,2组均连续治疗21 d。治疗21 d后,评价2组的临床疗效。分别于治疗前和治疗21 d后,检测2组患儿的血清胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ、胃泌素水平,测定胃排空时间、胃窦收缩频率、胃窦收缩幅度3项胃动力学指标,观察并统计患儿治疗期间不良反应的发生情况。结果:治疗后,研究组临床疗效总有效率96.25%,高于对照组的85.00%,差异有统计学意义(P<0.05)。2组胃排空时间均较治疗前缩短,胃窦收缩频率高于治疗前,胃窦收缩幅度大于治疗前,差异均有统计学意义(P<0.01);研究组胃排空时间短于对照组,胃窦收缩频率高于对照组,胃窦收缩幅度大于对照组,差异均有统计学意义(P<0.01)。2组血清胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ及胃泌素水平均较治疗前升高(P<0.01);研究组血清胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ及胃泌素水平均高于对照组(P<0.01)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小儿消食颗粒联合手法推拿治疗小儿脾胃虚弱型功能性消化不良可有效增强胃肠蠕动功能,调节胃蛋白酶原和胃泌素分泌水平,提高临床疗效,且安全性较高。

Objective:To observe the clinical effect of Xiao’er Xiaoshi granules combined with tuina with manipulation for children with functional dyspepsia of spleen stomach weakness type.Methods:A total of 160 cases of children with functional dyspepsia of spleen stomach weakness type were divided into the control group and the study group according to the random number table method,with 80 cases in each group.The control group was treated with the oral administration with bifidobacterium quadruple viable tablets,and the study group was additionally treated with tuina with manipulation based on the treatment of the control group.Both groups were continuously treated for 21 days.After 21-day treatment,clinical effects in the two groups were evaluated.Before and after 21-day treatment,the levels of serum pepsinogenⅠ,pepsinogenⅡand gastrin in the two groups were measured,and the three gastric motility indexes of gastric emptying time,gastric antrum contraction frequency and gastric antrum contraction amplitude were measured.The incidence of adverse reactions during treatment was observed and counted.Results:After treatment,the total effective rate was 96.25%in the study group,higher than that of 85.00%in the control group,the difference being significant(P<0.05).When compared with those before treatment,gastric emptying time in the two groups were shortened,gastric antrum contraction frequency higher,and gastric antrum contraction amplitude larger,differences being significant(P<0.01).After treatment,gastric emptying time in the study group was shorter than that in the control group,gastric antrum contraction frequency higher,and gastric antrum contraction amplitude larger,differences being significant(P<0.01).Levels of serum pepsinogenⅠ,pepsinogenⅡand gastrin in the two groups were increased when compared with those before treatment(P<0.01);levels of serum pepsinogenⅠ,pepsinogenⅡand gastrin in the study group were higher than those in the control group,differences being significant(P<0.01).There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P>0.05).Conclusion:In the treatment of children with functional dyspepsia of spleen stomach weakness type,Xiao’er Xiaoshi granules combined with tuina with manipulation can effectively enhance gastrointestinal peristalsis function,regulate the secretion of pepsinogen and gastrin,and improve clinical effects,with high safety.