消炎止痛膏治疗糖尿病患者胰岛素皮下硬结临床研究

Clinical Study on Xiaoyan Zhitong Ointment for Insulin Subcutaneous Induration in Patients with Diabetes

目的:观察消炎止痛膏治疗糖尿病患者胰岛素皮下硬结的临床效果。方法:选择采用胰岛素注射治疗后出现皮下硬结的2型糖尿病患者40例作为研究对象,依随机数字表法分为对照组与试验组各20例。2组均给予常规注射胰岛素治疗,对照组加用50%的硫酸镁溶液湿热敷患处,试验组加用消炎止痛膏涂抹患处。2组均连续治疗28 d,比较2组临床疗效、治疗前后血糖[空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbA1c)]水平、血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)]水平、血清炎症因子[C-反应蛋白(CRP)、白细胞介素-6(IL-6)]水平。结果:经秩和检验,试验组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗前,2组FBG、P2hBG、HbA1c、TC、TG、LDL水平比较,差异均无统计学意义(P>0.05);治疗后,2组FBG、P2hBG、HbA1c、TC、TG、LDL水平均未发生明显变化(P>0.05)。治疗前,2组CRP、IL-6水平比较,差异均无统计学意义(P>0.05);治疗后,2组CRP、IL-6水平均低于治疗前,且试验组CRP、IL-6水平低于对照组(P<0.05)。结论:针对糖尿病患者注射胰岛素导致的皮下硬结采用消炎止痛膏治疗,可在短期内改善皮下硬结的病变程度,缓解炎症反应,但对血糖、血脂水平无明显影响。

Objective:To observe the clinical effect of Xiaoyan Zhitong ointment for insulin subcutaneous induration in patients with diabetes.Methods:A total of 40 patients with type 2 diabetes mellitus who had subcutaneous induration after insulin injection were selected as the study subjects and divided into the experiment group and the control group according to the random number table method,with 20 cases in each group.Both groups were treated with routine insulin injection.The control group was additionally treated with wet-hot application of 50%magnesium sulfate solution,and the experiment group was additionally treated with Xiaoyan Zhitong ointment.The levels of blood glucose,including fasting blood glucose(FBG),postprandial 2 h blood glucose(P2hBG)and glycosylated hemoglobin(HbA1c),levels of blood lipids,including total cholesterol(TC),triglyceride(TG)and low-density lipoprotein(LDL),and levels of serum inflammatory factors,including Creactive protein(CRP)and interleukin-6(IL-6),before and after treatment and the clinical effects were compared between the two groups.Results:The clinical effect in the experiment group was better than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of FBG,P2hBG,HbA1c,TC,TG and LDL between the two groups(P>0.05);after treatment,the above indexes in the two groups did not change significantly(P>0.05).Before treatment,there was no significant difference being found in the comparison of levels of CRP and IL-6between the two groups(P>0.05);after treatment,the above levels in the two groups were lower than those before treatment,and the above levels in the experiment group were lower than those in the control group(P<0.05).Conclusion:The therapy of Xiaoyan Zhitong ointment for subcutaneous induration caused by insulin injection can improve the degree of lesion of subcutaneous sclerosis in the short term and alleviate the inflammatory responses,with no significant effect on levels of blood glucose and blood lipid.