美托洛尔联合瑞舒伐他汀钙治疗心绞痛的临床疗效及其对血脂的影响

Clinical effect of metoprolol combined with rosuvastatin calcium on treating angina pectoris and the impact on blood lipid of patients

目的 观察美托洛尔联合瑞舒伐他汀治疗心绞痛的临床疗效及其对血脂的影响。方法 选取2019年2月-2021年2月宜昌民福医院收治的120例心绞痛患者为研究对象,采用随机数字表法分为对照组和观察组,各60例。对照组予以美托洛尔治疗,观察组在对照组基础上加用瑞舒伐他汀钙治疗,2组均连续治疗3个月。比较2组临床疗效,治疗前后心绞痛发作次数、心绞痛持续时间、心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)],不良反应。结果 观察组总有效率为95.00%,高于对照组的81.66%(χ^(2)=5.175,P=0.023)。治疗后,2组心绞痛发作次数少于治疗前,心绞痛发作持续时间短于治疗前,且治疗后观察组心绞痛发作次数少于对照组,心绞痛发作持续时间短于对照组(P<0.01)。治疗后,2组LVESD、LVEDD短于治疗前,LVEF高于治疗前,且观察组LVESD、LVEDD短于对照组,LVEF高于对照组(P<0.05)。治疗后,2组TC、TG、LDL-C水平低于治疗前,HDL-C水平高于治疗前,且观察组TC、TG、LDL-C水平低于对照组,HDL-C水平高于对照组(P<0.01)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 美托洛尔联合瑞舒伐他汀钙治疗心绞痛患者的临床疗效确切,可有效减少心绞痛发作次数,缩短心绞痛持续时间,改善心功能,调节血脂代谢,且安全性较高。

Objective To analyze the effect of metoprolol combined with rosuvastatin calcium on treating angina pectoris and the impact on blood lipid of patients.Methods A total of 120 patients with angina pectoris were selected from Feburary 2019 to Feburary 2021 in Yichang Minfu Hospital,which were divided intocontrol group and observation group according to random number table method,60 cases in each group.Patients in control group were given metoprolol,patients in observation group were given rosuvastatin calcium based on control group,both groups were treated for 3 months.Clinical effect,frequency and duration of angina pectoris,cardiac function indexes(LVEDD,LVESD,LVEF),blood lipid indexes(TC,TG,HDL-C,LDL-C) before and after treatment,incidence of adverse reactions were compared between the two groups.Results Total effective rate in observation group was 95.00%,higher than 81.66%in control group(χ^(2)=5.175,P=0.023).After treatment,frequency of angina pectoris in the two groups was less than that before treatment,duration of angina pectoris was shorter than that before treatment,and frequency of angina pectoris of observation group was less than that in control group,duration of angina pectoris was shorter than that in control group(P<0.01).After treatment,LVESD,LVEDD in the two groups were lower than those before treatment,LVEF was higher than that before treatment,and LVESD,LVEDD of observation group were lower than those in control group,LVEF was higher than that in control group(P<0.05).After treatment,levels of TC,TG,LDL-C in the two groups were lower than those before treatment,HDL-C level was higher than that before treatment,and levels of TC,TG,LDL-C of observation group were lower than those in control group,HDL-C level was higher than that in control group(P<0.01).There was no significant difference of incidence of adverse reactions between the two groups(P>0.05).Conclusion Metoprolol combined withrosuvastatin calcium have an exact clinical effect in the treatment of angina pectoris,which can reduce frequency of angina pectoris,shorten duration of angina pectoris,improve cardiac function of patients,regulating blood lipid metabolism,and with higher safety.