不同严重程度的阻塞性睡眠呼吸暂停低通气综合征患者肺功能分析

Pulmonary Function in Patients with Obstructive Sleep Apnea Hypopnea Syndrome of Different Severity

目的:分析不同严重程度的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者肺功能。方法:选取2020年1月至2020年12月湖北省谷城县人民医院收治的OSAHS患者1000例作为研究对象,根据患者的呼吸暂停通气指数(Apnea-Hypopnea Index,AHI)将其进行分组,选取重度组(AHI≥30)的500例患者为观察组,中度及以下组(AHI<30)的500例患者为对照组,对所有患者进行肺功能检查及多导睡眠监测(PSG),比较2组患者的肺活量以及其他的肺功能指标。结果:观察组最低血氧浓度(SPO_(2))明显低于对照组,观察组的最长呼吸暂停时间高于对照组,肺活量(VC)、功能残气量(FRC)、补呼吸气量(ERV)均显著低于对照组,观察组动脉血二氧化碳分压(PaCO_(2))、降钙素(PCT)、C-反应蛋白(CRP)均高于对照组,观察组第1秒用力呼气容积(FEV_(1))、白细胞介素/肺总量(IL/TLC)、1秒率(FEV_(1)/FVC)均显著低于对照组,2组比较差异均有统计学意义(均P<0.05)。结论:OSAHS患者由于病症的严重程度不同,使得患者的肺功能指标不尽相同,所以在临床中需要根据患者病症的严重程度来进行更有针对性的治疗,提高患者的治疗效果。

Objective:To analyze the lung function of patients with obstructive sleep apnea hypopnea syndrome(OSAHS)with different severity.Methods:A total of 1000 patients with OSAHS admitted to Gucheng People′s Hospital from January 2020 to December 2020 were selected as the research objects.Patients were divided into groups according to apnea hypopnea index(AHI).Five hundred patients in the severe group(AHI≥30)were selected as the observation group,and 500 patients in the moderate and below group(AHI<30)were selected as the control group.Lung function examination and polysomnography monitoring(PSG)were performed in all patients,and lung capacity and other lung function indicators were compared at the same time.Results:The lowest blood oxygen concentration(SPO_(2))in the observation group was significantly lower than that of the control group,the longest apnea time in the observation group was significantly higher than the control group,and the vital capacity(VC),functional residual capacity(FRC)and expiratory reserve volume(ERV)in the observation group were significantly lower than the control group.Arterial partial pressure of carbon dioxide(PaCO_(2)),calcitonin(PCT)and C-reactive protein(CRP)in observation group were higher than the control group,forced expiratory volume in 1 second(FEV_(1)),total volume of interleukin/lung(IL/TLC)and rate of 1 second(FEV_(1)/FVC)in observation group were significantly lower than the control group.The differences between the two groups were statistically significant(Ps<0.05).Conclusion:Patients with OSAHS have different lung function indicators due to different severity of symptoms,so more targeted treatment should be carried out according to the severity of symptoms in clinical practice to improve the therapeutic effect of patients.