CD38和CD138及MUM-1在慢性子宫内膜炎病理诊断中的应用

Application of CD38,CD138 and MUM-1 in the pathological diagnosis of chronic endometritis

目的:探讨CD38,CD138和MUM-1对慢性子宫内膜炎的诊断意义。方法:收集2018年1月—2021年8月3712例临床怀疑子宫内膜炎患者的活组织检查标本,用苏木精—伊红染色法(HE)及免疫组化EnVision法检测CD38,CD138和MUM-1在3712例临床怀疑子宫内膜炎患者的活组织检查标本中的表达,观察不同抗体在慢性子宫内膜炎诊断中的价值。结果:HE染色和免疫组化CD38,CD138,MUM-1的阳性率分别为12.04%,33.81%,24.16%和24.57%;CD38,CD138和MUM-1检测的特异性分别为70.99%,99.33%和97.69%。结论:慢性子宫内膜炎,应用CD138和/或MUM-1进行免疫组化染色可有效检测子宫内膜间质中的浆细胞,而CD38检测浆细胞的敏感性虽高,但特异性较差。

Objective:To investigate the expression of CD38,CD138 and MUM-1 in chronic endometritis tissue and to seek for their possible relationship.Methods:The expression of hematoxylin-eosin staining(HE),CD38,CD138 and MUM-1 in 3712 case of suspected endometritis was examined with immunohistochemical technique(EnVision)to observe the expression of different immunohistochemical antibodies in endometrial stroma.Results:The positive rates of HE,CD38,CD138 and MUM-1 were 12.04%,33.81%,24.16% and 24.57%,respectively.The specificity of CD38,CD138,and MUM-1were 70.99%,99.33%和97.69%,respectively.Conclusion:Immunohistochemical staining with CD138 and/or MUM-1 for chronic endometritis can effectively detect plasma cells in the endometrium,while CD38 has poor specificity for plasmocyte.