异鼠李素抗癌作用及其机制的研究进展

Research progress on anticancer effect and mechanism of isorhamnetin

肿瘤目前仍是威胁人类健康,加重社会医疗负担的重要因素,探寻高效低毒的植物衍生抗肿瘤药物被认为是肿瘤患者进行有效治疗和提高生存质量的重要思路。异鼠李素是一种广泛存在于多种植物的天然小分子黄酮类化合物,具有抗炎、抗病毒、抗心肌缺氧缺血和降脂等多种生物学功能。近年来的研究发现,异鼠李素可作为一种抗肿瘤药物在多种肿瘤细胞中发挥抗癌作用,其作用机制主要包括促进癌细胞凋亡、诱导癌细胞自噬、抑制其侵袭及转移、增强化疗敏感性等。本文综述异鼠李素的抗癌作用及其机理,旨在为今后异鼠李素的抗癌机制研究及肿瘤治疗提供新思路和策略。

Tumor is still an important factor that threatens human health and increases the social medical burden. The search for plant-derived antitumor drugs with high efficiency and low toxicity is considered to be an important idea for effective treatment and improving the quality of life of tumor patients. Isorhamnetin is a natural small-molecule flavonoid that widely exists in a variety of plants, and has various biological functions such as anti-inflammatory, antiviral, anti-myocardial hypoxia-ischemia, and lipid-lowering. Recent studies have found that isorhamnetin can act as an anti-tumor drug to exert anti-cancer effects in a variety of tumor cells, and its mechanism of action mainly includes promoting cancer cell apoptosis, inducing cancer cell autophagy, inhibiting its invasion and metastasis, enhance chemotherapy sensitivity, and other processes. This article reviews the anticancer effect and mechanism of isorhamnetin,aiming to provide new ideas and strategies for future research on the anticancer mechanism of isorhamnetin and tumor therapy.