尿FSP-1、β2-MG与过敏性紫癜患儿病情严重程度的关系及预后影响因素分析

Relationship between urinary FSP-1, β2-MG and severity of henoch-schonlein purpura in children and prognosis factors analysis

目的 探讨尿纤维母细胞标志蛋白1(FSP-1)、β2-微球蛋白(β2-MG)与过敏性紫癜(HSP)患儿病情严重程度及对预后影响因素分析。方法 选取2018年1月到2020年12月安徽理工大学第一附属医院(以下简称“我院”)儿科收治的HSP患儿110例为HSP组,同期来我院门诊进行健康咨询的100名健康儿童为对照组。比较两组尿FSP-1、β2-MG水平,分析其与紫癜症状评分的相关性。以患儿入院1周内是否发生肾脏损伤分为肾损伤组和未损伤组,分析影响HSP预后不良的危险因素。结果 HSP组尿FSP-1、β2-MG水平高于对照组,差异有统计学意义(P <0.05)。Pearson相关性分析显示,尿FSP-1、β2-MG水平与紫癜症状评分呈正相关(r> 0,P <0.05)。110例中有35例发生肾损伤,两组腹痛、IgA、尿FSP-1、尿β2-MG、紫癜症状评分比较,差异有统计学意义(P <0.05)。logistic回归分析显示,腹痛、IgA、尿FSP-1、β2-MG、紫癜症状评分为预后不良的影响因素(OR> 1,P <0.05)。结论 HSP患儿存在尿FSP-1、β2-MG水平异常且与病情严重程度呈正相关,是导致患儿预后不良的危险因素。

Objective To investigate the severity of urinary fibroblast marker protein-1(FSP-1), β2-microglobulin(β2-MG) of children with henoch-schonlein purpura(HSP) and the factors affecting prognosis. Methods From January2018 to December 2020, 110 children with HSP admitted to the Department of Pediatrics, the First Affiliated Hospital of Anhui University of Science and Technology(“our hospital” for short) were selected as HSP group. During the same period, 100 healthy children who came to our hospital for health consultation were control group. The levels of urinary FSP-1 and β2-MG were compared between two groups, and the correlation between the levels and purpura symptoms scores was analyzed. The children were divided into kidney injury group and non-injury group according to whether kidney injury occurred within one week after admission, and the risk factors influencing poor prognosis of HSP were analyzed. Results The levels of urinary FSP-1 and β2-MG in HSP group were higher than those in control group, and the differences were statistically significant(P < 0.05). Pearson correlation analysis showed that urinary FSP-1 and β2-MG levels were positively correlated with purpura symptom scores(r > 0, P < 0.05). There were 35 cases of renal injury in 110 cases, and there were statistically significant differences in abdominal pain, IgA, urinary FSP-1, urinaryβ2-MG, and purpura symptom scores between two groups(P < 0.05). Logistic regression analysis showed that abdominal pain, IgA, urinary FSP-1, β2-MG, and purpura symptom score were the effect factors for poor prognosis(OR > 1, P <0.05). Conclusion Abnormal levels of urinary FSP-1 and β2-MG in children with HSP and positively correlated with the severity of the disease, which are risk factors leading to poor prognosis.