奥硝唑联合米诺环素经根管给药治疗牙周牙髓综合征患者的效果

Effects of Ornidazole combined with Minocycline administration through root canal in treatment of patients with periodontal pulp syndrome

目的:观察奥硝唑联合米诺环素经根管给药治疗牙周牙髓综合征患者的效果。方法:选取120例牙周牙髓综合征患者为研究对象,采用随机数字表法将其分为观察组60例(65颗)和对照组60例(68颗)。对照组给予米诺环素根管给药治疗,观察组在对照组基础上联合奥硝唑根管给药治疗,比较两组临床疗效、牙周相关指标[牙龈指数(GI)、牙周探诊深度(PD)、龈沟出血指数(SBI)]水平、疼痛程度[视觉模拟评分法(VAS)]评分、炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平和不良反应发生率。结果:观察组治疗总有效率为95.00%(57/60),高于对照组的81.67%(49/60),差异有统计学意义(P<0.05);治疗后,观察组SBI、PD、GI等牙周相关指标水平均低于对照组,差异有统计学意义(P<0.05);观察组治疗3、7、14 d后VAS评分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:奥硝唑联合米诺环素经根管给药治疗牙周牙髓综合征患者可提高治疗总有效率,降低牙周相关指标水平、VAS评分和炎性指标水平,其效果优于单纯米诺环素根管给药治疗。

Objective:To observe effects of Ornidazole combined with Minocycline administration through root canal in treatment of patients with periodontal pulp syndrome.Methods:120 patients with periodontal pulp syndrome were selected as the research objects,and were divided into observation group of 60 cases(65 teeth)and control group of 60 cases(68 teeth)by random number method.The control group was given Minocycline through root canal,while the observation group was combined with Ornidazole root canal administration on the basis of that of the control group.The clinical effects,the periodontal-related indicator levels[gingival index(GI),periodontal probing depth(PD),sulcus bleeding index(SBI)],the pain severity[visual analogue scale(VAS)]score,the inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.00%(57/60),which was higher than 81.67%(49/60)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of SBI,PD,GI and other periodontal-related indicators in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The VAS scores of the observation group on 3,7,and 14 days were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6 and TNF-αin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ornidazole combined with Minocycline administration through root canal in the treatment of the patients with periodontal pulp syndrome can improve the total effective rate of treatment,and reduce the periodontal-related indicator levels,the VAS score and the inflammatory indicator levels.Moreover,it is superior to single Minocycline root canal administration.