七味白术散联合匹维溴铵治疗腹泻型肠易激综合征脾胃虚弱证患者的效果

Effects of Qiwei Baizhu powder combined with Pinaverium bromide in treatment of diarrhea-type irritable bowel syndrome patients with spleen-stomach deficiency syndrome

目的:观察七味白术散联合匹维溴铵治疗腹泻型肠易激综合征(IBS-D)脾胃虚弱证患者的效果。方法:选取100例IBS-D患者为研究对象,按随机数字表法分为对照组和观察组,各50例。对照组采用匹维溴铵治疗,观察组在对照组基础上加用七味白术散治疗,两组均持续用药4周。比较两组临床疗效、治疗前后临床症状评分、生命质量[世界卫生组织生存质量测定量表简表(WHOQOL-BREF)]评分,以及复发率和不良反应发生率。结果:观察组治疗总有效率为94.00%(47/50),高于对照组的80.00%(40/50),差异有统计学意义(P<0.05);治疗后,观察组腹痛、腹泻和腹胀等临床症状评分均低于对照组,心理、生理、环境及社会领域等WHOQOL-BREF评分均高于对照组,差异有统计学意义(P<0.05);观察组复发率为4.26%(2/47),低于对照组的22.50%(9/40),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:七味白术散联合匹维溴铵治疗IBS-D患者可提高治疗总有效率和生命质量评分,降低临床症状评分和复发率,效果优于单纯匹维溴铵治疗。

Objective:To observe effects of Qiwei Baizhu powder combined with Pinaverium bromide in treatment of diarrhea-type irritable bowel syndrome(IBS-D)patients with spleen-stomach deficiency syndrome.Methods:100 patients with IBS-D were selected as the research objects,and were divided into control group and observation group according to the random number table method,50 cases in each group.The control group was treated with Pinaverium bromide,while the observation group was additionally treated with Qiwei Baizhu powder on the basis of that of the control group.Both groups were treated continuously for 4 weeks.The clinical effects,the clinical symptom scores before and after the treatment,the quality of life[world health organization quality of life-brief(WHOQOL-BREF)]score,the recurrence rate and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 94.00%(47/50),which was higher than 80.00%(40/50)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the clinical symptom scores such as abdominal pain,diarrhea and abdominal distension in the observation group were lower than those in the control group;the WHOQOLBREF scores in psychology,physiology,environment and social domains were all higher than those in the control group;and the differences were statistically significant(P<0.05).The recurrence rate in the observation group was 4.26%(2/47),which was lower than 22.50%(9/40)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Qiwei Baizhu powder combined with Pinaverium bromide in treatment of the IBS-D patients can improve the total effective rate and the quality of life score,and reduce the clinical symptom score and the recurrence rate.Moreover,it is superior to single Pinaverium bromide.