脓毒症动物模型的制备方法及影响因素

Construction Methods and Influencing Factors on Animal Model of Sepsis

脓毒症是常见的急危重症,其致病机制复杂,常涉及全身多个器官、系统,其中炎性反应、免疫功能紊乱、凝血功能障碍等多种因素联结成相互联系、相互影响的网络系统,加重病情进展。目前脓毒症病死率约25%,严重威胁人类健康。建立稳定可靠的脓毒症实验动物模型是了解感染早期宿主防御调控机制、病情进展期宿主反应失调机制及研究新型药物治疗效果的重要手段。目前脓毒症动物模型的建立方法种类繁多,且影响因素较多。本文就脓毒症动物模型的制备方法及影响因素进行综述,以期为研究者选择合适的动物模型提供参考。

Sepsis is a common acute and critical illness,and its pathogenic mechanism is complex,often involving multiple organs and systems in the body.Various factors such as inflammatory response,immune dysfunction,and coagulation dysfunction are connected into an interconnected and mutually influencing network system,aggravating the severity of the disease.At present,the case fatality rate of sepsis is about 25%,which is a serious threat to human health.Establishing a stable and reliable experimental animal model of sepsis is an important means to understand the mechanism of host defense regulation in the early stage of infection,the mechanism of host response disorder in the stage of disease progression and to study the therapeutic effect of new therapeutic drugs.At present,there are many methods to establish animal models of sepsis,and there are many influencing factors.Therefore,this paper reviewed the preparation methods and influencing factors of animal models of sepsis,in order to provide some references for researchers to select suitable animal models.