胃癌类器官在精准医学研究中的应用

Application of Gastric Cancer Organoids in Precision Medicine Research

类器官是利用干细胞或来源于患者组织建立起来的一种体外三维培养系统。运用该培养技术,正常胃类器官和胃癌类器官均可建立起来。类器官具有高保真性,尤其是可保留其来源组织中的分子结构、功能特征和遗传信息等,可用于治疗靶点筛选和药物反应预测及验证,为胃癌精准医学研究及实验动物替代研究提供了新的思路。本文综述了目前胃癌类器官模型的建立情况,以及类器官与精准医学的发展前景等,为胃癌类器官应用于精准医学研究提供理想的体外模型参考。

Organoid is an in vitro three-dimensional culture system of stem cells or tissues derived from patients.Both normal gastric organoids and gastric cancer organoids can be established through this culture technique.Organoid possesses high fidelity,it grows with the similar molecular structures,functional characteristics,and genetic information as its tissue-of-origin.According to above,organoid can perform therapeutic targets screen,facilitate drug responses prediction and verification.Meanwhile,it also provides a new idea for precision medicine research of gastric cancer and replacement research of laboratory animals.This paper reviewed the establishment of organoid model of gastric cancer and the development of application of organoid in precision medicine,to provide ideal in vitro models reference for precision medicine research of gastric cancer.