金黄色葡萄球菌的致病机制

Pathogenic Mechanism of Staphylococcus Aureus

金黄色葡萄球菌是引起肺炎、菌血症等多种感染性疾病的重要革兰阳性病原菌。随着其感染发病率的增高,耐药甚至多耐药菌株在临床上陆续出现,治疗难度加剧,致死率高。金黄色葡萄球菌的致病机制与其自身产生的多种毒力因子有关,目前广泛研究的毒素主要包括溶血素、葡萄球菌肠毒素、中毒性休克综合征毒素-1和杀白细胞素等。各种毒力因素决定了金黄色葡萄球菌的致病性。未来随着对金黄色葡萄球菌常见毒力因子的不断研究,基因靶向治疗等新兴疗法将具有广泛应用前景。

Staphylococcus aureus is an important Gram-positive pathogen with worldwide distribution that causes various infectious diseases including pneumonia and bacteremia.With the increase of the infection incidence,drug-resistant and even multi-drug-resistant strains appear one after another in clinic,which makes the treatment more difficult and the fatality rate high.The pathogenic mechanism of Staphylococcus aureus is related to a variety of virulence factors produced by Staphylococcus aureus.At present,the widely studied toxins include hemolysin,Staphylococcal enterotoxin,toxic shock syndrome toxin-1,leukocidin and so on.Various virulence factors determine the pathogenicity of Staphylococcus aureus.In the future,with the continuous study of common virulence factors of Staphylococcus aureus,new therapies such as gene targeting therapy will have a wide application prospect.