补阳还五汤治疗气虚血瘀证急性脑梗死患者的效果及对血流动力学指标和血液黏度的影响

Effect of Buyang Huanwu Decoction on Acute Cerebral Infarction Patients with Qi Deficiency and Blood Stasis Syndrome and Its Influence on Hemodynamic Indexes and Blood Viscosity

目的:补阳还五汤治疗气虚血瘀证急性脑梗死患者的效果及对血流动力学指标和血液黏度的影响。方法:选取2020年9月-2021年4月佳木斯市中医院收治的70例气虚血瘀证急性脑梗死患者,按照随机数字表法将其分为对照组和研究组,每组35例。对照组应用阿司匹林肠溶片治疗,研究组在对照组基础上应用补阳还五汤治疗。比较两组血流动力学、血液黏度及血管斑块情况。结果:治疗前,两组纤维蛋白原、红细胞沉降率、红细胞聚集指数比较,差异均无统计学意义(P>0.05);治疗后,研究组纤维蛋白原、红细胞沉降率、红细胞聚集指数均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组斑块数量、面积及厚度比较,差异均无统计学意义(P>0.05);治疗后,研究组斑块数量少于对照组,斑块面积及厚度均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组全血高切黏度、全血低切黏度、血浆黏度和血管内皮生长因子(VEGF)水平比较,差异均无统计学意义(P>0.05);治疗后,研究组全血高切黏度、全血低切黏度、血浆黏度均低于对照组,VEGF水平高于对照组,差异均有统计学意义(P<0.05)。结论:气虚血瘀证急性脑梗死患者治疗过程当中,补阳还五汤治疗效果理想,可改善血流动力学指标及血液黏度,同时可减小血管斑块数量、面积及厚度,值得广泛应用。

Objective:To explore effect of Buyang Huanwu Decoction on acute cerebral infarction patients with qi deficiency and blood stasis syndrome and its influence on hemodynamic indexes and blood viscosity.Method:A total of 70 patients with acute cerebral infarction with qi deficiency and blood stasis syndrome admitted to Jiamusi Hospital of Traditional Chinese Medicine from September 2020 to April 2021 were selected,they were divided into control group and study group according to random number table method,with 35 cases in each group.The control group was treated with Aspirin Enteric-coated Tablet,and the study group was treated with Buyang Huanwu Decoction on the basis of the control group.Hemodynamics,blood viscosity and vascular plaque were compared between two groups.Result:Before treatment,there were no significant differences in fibrinogen,erythrocyte sedimentation rate and erythrocyte aggregation index between two groups(P>0.05);after treatment,fibrinogen,erythrocyte sedimentation rate and erythrocyte aggregation index in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the number,area and thickness of plaque between two groups(P>0.05);after treatment,the number of plaques in the study group was less than that in the control group,and the area and thickness of plaques were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity and vascular endothelial growth factor(VEGF)levels between two groups(P>0.05);after treatment,whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity in the study group were lower than those in the control group,while VEGF level in the study group was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion:In the treatment of acute cerebral infarction patients with qi deficiency and blood stasis syndrome,Buyang Huanwu Decoction has ideal therapeutic effect,which can improve hemodynamic indexes and blood viscosity,and reduce the number,area and thickness of vascular plaques,it is worth extensive application.