妇女HPV感染特征及影响因素分析

Analysis of Characteristics and Influencing Factors of HPV Infection in Women

目的:研究妇女HPV感染特征及影响因素。方法:选取2019年1月-2021年1月吉安市儿童医院收治的2692例接受HPV检查患者,分析HPV亚型分布特点、感染年龄分布及感染影响因素。结果:2692例受检者中,584例呈HPV阳性表现,HPV阳性检出率为21.69%。低危型感染、高危型感染例数分别为180、404例,检出率分别为6.69%、15.01%。584例HPV阳性患者中,三重及以上感染、双重感染、单一感染例数分别为54、92、438例,占比分别为9.25%、15.75%、75.00%;2692例受检者中,共检出808株HPV亚型,其中HPV16、HPV6亚型比例较高,分别为20.05%、17.82%。50~65岁、17~29岁年龄段相对其他年龄段,HPV阳性检出率更高,分别为28.3%、33.5%。不同居住地区、家庭收入、婚姻状况及性伴侣个数人群HPV阳性检出率比较,差异均有统计学意义(P<0.05);不同文化程度、初次性生活年龄、生育次数及是否口服避孕药、是否抽烟、是否绝经人群HPV阳性检出率比较,差异均无统计学意义(P>0.05)。结论:加强HPV检测是降低HPV感染率的重要因素,同时有利于了解HPV感染亚型分布特点与状况,对临床治疗具有重要意义。

Objective:To study the characteristics and influencing factors of HPV infection in women.Method:A total of 2692 patients who underwent HPV examination in Ji’an Children’s Hospital from January 2019 to January 2021 were selected.The distribution characteristics of HPV subtypes,infection age distribution and infection influencing factors were analyzed.Result:Among the 2692 subjects,584 cases were HPV positive,the positive detection rate of HPV was 21.69%.The number of low-risk infection and high-risk infection were 180 and 404 respectively,the detection rates were 6.69%and 15.01%respectively.Among 584 HPV positive patients,the number of triple and above infection,double infection and single infection were 54,92 and 438 respectively,accounting for 9.25%,15.75%and 75.00%respectively.A total of 808 HPV subtypes were detected in 2692 subjects.The proportion of HPV16 and HPV6 subtypes were 20.05%and 17.82%respectively.The positive detection rates of HPV in the age group of 50-65 and 17-29 were higher than those in other age groups,which were 28.3%and 33.5%respectively.There were significant differences in HPV positive rates among people in different living areas,family income,marital status and the number of sexual partners(P<0.05);there were no significant differences in HPV positive rates among people with different educational levels,age of first sexual life,number of births,oral contraceptives,smoking and menopause(P>0.05).Conclusion:Strengthening HPV detection is an important factor to reduce HPV infection rate,and it is helpful to understand the distribution characteristics and status of HPV infection subtypes,which is of great significance for clinical treatment.