自拟化浊解毒方治疗急性特发性前葡萄膜炎的临床观察

Clinical Efficacy of Self-made Huazhuo Jiedu Formula in the Treatment of Idiopathic Acute Anterior Uveitis

目的验证自拟化浊解毒方治疗急性特发性前葡萄膜炎的临床有效性和安全性。方法选取2017年1月—2020年1月期间于河北省中医院门诊治疗的急性特发性前葡萄膜炎患者80例(80只眼),随机分为对照组与治疗组,每组各40例(40只眼)。对照组予以复方托吡卡胺滴眼液及硫酸阿托品眼用凝胶散瞳,普拉洛芬滴眼液及妥布霉素地塞米松滴眼液抗炎治疗,治疗组在对照组基础上加自拟化浊解毒方口服治疗。两组患者治疗14 d后,观察比较两组患者最佳矫正视力(Best corrected visual acuity,BCVA)、前房闪辉、前房细胞、红细胞沉降率(Erythrocyte sedimentation rate,ESR)、丙氨酸氨基转移酶(Alanine aminotransferase,ALT)及血清肌酐(Serum creatinine,Scr)指数情况。结果治疗后两组患者BCVA均优于治疗前,差异有统计学意义(P<0.05);两组患者BCVA组间比较,差异无统计学意义(P>0.05)。治疗后两组患者前房细胞和前房闪辉等级均较治疗前明显改善,差异有统计学意义(P<0.05);且治疗组前房细胞等级优于对照组,差异有统计学意义(P<0.05),前房闪辉等级与对照组比较,差异无统计学意义(P>0.05)。治疗后两组患者ESR数值均较治疗前降低,差异有统计学意义(P<0.05);ALT、Scr数值治疗前后、治疗后组间比较,差异均无统计学意义(P>0.05)。结论自拟化浊解毒方治疗急性特发性前葡萄膜炎患者疗效确切,患者最佳矫正视力和前房反应得到有效改善,且中药组方药物具有安全性,值得临床推广。

Objective To verify the clinical efficacy and safety of self-made Huazhuo Jiedu Formula in the treatment of idiopathic acute anterior uveitis.Methods A total of 80 patients(80 eyes)with idiopathic acute anterior uveitis treated in the outpatient department of Hebei Provincial Hospital of Traditional Chinese Medicine from January 2017 to January 2020 were enrolled in this study.According to the random grouping method,they were assigned into a control group and a study group,with 40 patients(40 eyes)in each group.The patients in the control group received Compound Tropicamide Eye Drops and Atropine Sulfate Eye Gel for mydriasis,and Pranoprofen Eye Drops and Tobramycin and Dexamethasone Eye Drops for anti-inflammatory treatment.On the basis of the therapy in the control group,the patients in the study group received oral administration of self-made Huazhuo Jiedu Formula.The treatments in both groups lasted for 14 days.The best corrected visual acuity(BCVA),anterior chamber flare,aqueous cells,erythrocyte sedimentation rate(ESR),alanine aminotransferase(ALT)level,and serum creatinine(Scr)level were measured and compared.Results After treatment,the BCVA of the two groups improved compared with that before treatment(P<0.05),while it showed no significant difference between the two groups(P>0.05).The treatments in both groups improved the aqueous cell grade and anterior chamber flare(P<0.05).Moreover,the aqueous cell grade was higher in the study group than in the control group(P<0.05),while the anterior chamber flare showed no significant difference between the two groups(P>0.05)after treatment.The treatments in both groups lowered the ESR(P<0.05),but the value within the group after treatment was lower than that before treatment(P>0.05).The ALT and Scr levels showed no significant difference between before and after treatment or between the two groups(P>0.05).Conclusion The self-made Huazhuo Jiedu Formula can improve BCVA and alleviate anterior chamber flare,demonstrating remarkable therapeutic effect on idiopathic acute anterior uveitis.The medicinalherbs in the formula are safe,and the formula is worthy of clinical promotion.