摘要
由于全球经济的快速发展、工业化和现代化进程的加快,大气污染所引发的健康问题日益严重,其中大气颗粒物(Particulate Matter,PM)暴露对于肾脏的直接毒性正逐渐受到重视。国内外流行病学研究证实,PM对慢性肾脏病发生发展有重要影响。本文针对PM,包括PM_(10)(Particulate Matter≤10μm)、PM_(2.5)(Particulate Matter≤2.5μm)和PM_(1)(Particu-late Matter≤1μm)等与慢性肾脏病的相关性及其影响机制进行综述,为人群PM暴露干预政策制定和慢性肾脏病防控策略应对提供依据。
The effect of air pollution on human health becomes a severe public health challenge due to rapid development in global economy and industrialized urbanization.Particulate matter(PM)is one of the major air pollutants and its renal toxicity has gained accumulating attention.Epidemiological evidence identified that the PM contributes to the development and progression of chronic kidney disease(CKD).This paper reviews the effects of PMs(PM_(10),PM_(2.5)and PM_(1))on CKD and its underlying mechanisms,which provides evidence for control of PM and strategy of managing CKD.
作者
陈睿
楚红
李鹏飞
王晋伟
王福琳
杨超
张路霞
Chen Rui;Chu Hong;Li Pengfei;Wang Jinwei;Wang Fulin;Yang Chao;Zhang Luxia(Peking University First Hospital,Beijing 100034,China;Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases,Chinese Academy of Medical Sciences,Beijing 100034,China;Advanced Institute of Information Technology,Peking University,Hangzhou 311215,Zhejiang,China;Institute of Medical Technology,Peking University Health Science Center,Beijing 100191,China;National Institute of Health Data Science at Peking University,Beijing 100191,China;Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases,Chinese Academy of Medical Sciences,Beijing 100191,China)
出处
《生物医学转化》
2022年第2期2-8,共7页
Biomedical transformation
基金
国家自然科学基金(72125009,82003529)
中国医学科学院医学与健康科技创新工程项目(2019-I2M-5-046,2021RU003)
北大百度基金(2020BD004,2020BD005)。
