尿促性素联合克罗米芬治疗排卵障碍性不孕症患者的临床效果观察

Observation on the clinical effect of menotrophin combined with clomiphene on patients with infertility caused by ovulation disorder

目的 探讨尿促性素联合克罗米芬治疗排卵障碍性不孕症患者的临床效果。方法 124例排卵障碍性不孕症患者作为研究对象,采用随机数字表法分为对照组与观察组,各67例。对照组予以尿促性素治疗,观察组予以尿促性素联合克罗米芬治疗。比较两组治疗前后各项性激素指标[黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、孕酮(P)]水平、妊娠情况及排卵情况。结果 治疗后,两组LH、FSH比较,差异无统计学意义(P>0.05);观察组E2、P水平分别为(345.23±83.25)pmol/L、(14.75±1.58)ng/ml,均高于对照组的(295.23±79.23)pmol/L、(10.98±1.28)ng/ml,差异有统计学意义(P<0.05)。观察组妊娠率及排卵率分别为58.21%、94.03%,均明显高于对照组的29.85%、76.12%,差异均有统计学意义(P<0.05)。结论 将尿促性素、克罗米芬联合应用于排卵障碍性不孕症患者的治疗效果明显,不仅利于改善排卵障碍,促进患者获得正常卵泡,还能提升妊娠率及排卵率,效果较好,值得临床大力推广并应用。

Objective To discuss the clinical effect of menotrophin combined with clomiphene on patients with infertility caused by ovulation disorder. Methods A total of 124 patients with infertility caused by ovulation disorder were selected as the research subjects, and were divided into the control group and the observation group by random numerical table, with 67 cases in each group. The control group was treated with menotrophin, and the observation group was treated with menotrophin combined with clomiphene. The levels of various sex hormone indexes [luteinizing hormone(LH), follicle stimulating hormone(FSH), estradiol(E2), progesterone(P)] before and after treatment, pregnancy rate and ovulation rate were compared between the two groups. Results After treatment, there was no statistically significant difference in LH and FSH between the two groups(P>0.05);the levels of E2 and P in the observation group were(345.23±83.25) pmol/L and(14.75±1.58) ng/ml, which were higher than(295.23±79.23) pmol/L and(10.98±1.28) ng/ml in the control group, and the difference was statistically significant(P<0.05). The pregnancy rate and ovulation rate of the observation group were 58.21% and 94.03%, which were significantly higher than 29.85% and 76.12%of the control group, and the difference was statistically significant(P<0.05). Conclusion The combination of menotrophin and clomiphene has obvious effect in the treatment of infertility caused by ovulation disorder. It is not only conducive to improve ovulation disorder and promote patients to obtain normal follicles, but also improve the pregnancy rate and ovulation rate. It is worthy of clinical promotion and application.