抗氧化剂在男性不育症治疗中的研究进展

Research progress of antioxidants in the treatment of male infertility

氧化应激使精子内活性氧水平提高、线粒体膜电位下降,引起精子膜脂质过氧化反应、精子DNA的易损性及精子线粒体数量减少,对精子数量、浓度、活力和形态产生负面影响。近年研究发现将抗氧化剂应用于少精、弱精、畸精等男性生殖问题,取得较好的效果。本文就抗氧化剂维生素E、辅酶Q10、硒、硫辛酸和其他抗氧化剂在男性不育症中的研究进展做一综述,以期为抗氧化剂在男性生殖中的后续研究提供参考。

Oxidative stress increases the level of reactive oxygen species in sperm and decreases the mitochondrial membrane potential,leading to lipid peroxidation of sperm membrane,the vulnerability of sperm DNA and the reduction of sperm mitochondrial number,which negatively affects the number,concentration,motility and morphology of sperm.In recent years,it has been found that the application of antioxidant in male reproductive problems such as oligospermia,weak spermatospermia and abnormal spermatospermia has achieved good results.This article reviews the research progress of antioxidant vitamin E,coenzyme Q10,selenium,lipoic acid and other antioxidants in male infertility,in order to provide reference for the follow-up research of antioxidant in male reproduction.