血清视黄醇结合蛋白、胱抑素C、基质金属蛋白酶9与急性脑梗死患者颈动脉粥样硬化的相关性

The relationship between RBP,Cys-C,MMP9 and carotid atherosclerosis in patients with acute cerebral infarction

目的:分析血清视黄醇结合蛋白(RBP)、胱抑素C(Cys-C)、基质金属蛋白酶(MMP)-9联合检测与急性脑梗死(ACI)患者颈动脉粥样硬化的关系。方法:采用回顾性方法,收集112例ACI患者作为ACI组,同期选取100例健康体检者作为对照组,分别对两组进行RBP、Cys-C、MMP-9水平检测。ACI组根据超声检查颈动脉内的中膜厚度分为正常组31例、轻度狭窄组22例、中度狭窄组29例、重度狭窄组30例,根据斑块的形成分为无斑块组28例、稳定斑块组45例、不稳定斑块组39例。结果:ACI组RBP、Cys-C、MMP-9、颈动脉内-中层厚度(IMT)值显著高于对照组,差异有统计学意义(P<0.05);随着颈动脉狭窄程度的增加,RBP、Cys-C、MMP-9水平在轻度狭窄组、中度狭窄组、重度狭窄组中逐渐升高,差异有统计学意义(P<0.05);ACI组稳定斑块组和不稳定斑块组RBP、Cys-C、MMP-9水平明显高于无斑块组,不稳定斑块组高于斑块稳定组,差异有统计学意义(P<0.05);Pearson相关性分析显示ACI患者颈动脉IMT值与血清RBP、Cys-C、MMP-9水平呈明显正相关。结论:血清RBP、Cys-C、MMP-9水平在ACI患者中明显升高,并且与颈动脉粥样硬化的程度、斑块性质密切相关。

Objective To analyze the relationship between serum retinol-binding protein(RBP),cystatin C(Cys-C),matrix metalloproteinase(MMP)-9 combined detection and carotid atherosclerosis in patients with acute cerebral infarction(ACI).Method Retrospectively,112 patients with ACI admitted to hospital were selected as the ACI group,and 100 healthy subjects were selected as the control group during the same period.RBP,Cys-C and MMP-9 levels were detected in the two groups,respectively.The ACI group was divided into normal group(31 cases),mild stenosis group(22 cases),moderate stenosis group(29 cases)and severe stenosis group(30 cases)according to the thickness of the media in the carotid artery by ultrasound examination,and non-plaque group(28 cases),stable plaque group(45 cases)and unstable plaque group(39 cases)according to the formation of plaque.Results The values of RBP,Cys-C,MMP-9 and IMT in ACI group were significantly higher than those in control group(P<0.05).With the degree of carotid artery stenosis increasing,the levels of RBP,Cys-C and MMP-9 were gradually increased in mild stenosis group,moderate stenosis group and severe stenosis group(P<0.05).The levels of RBP,Cys-C and MMP-9 in ACI stable plaque group and unstable plaque group were significantly higher than those in non-plaque group,and those in unstable plaque group were higher than those in stable plaque group(P<0.05).Pearson correlation analysis showed that the carotid IMT value was significantly positively correlated with the serum RBP,Cys-C and MMP-9 levels in ACI patients.Conclusion Serum RBP,Cys-C and MMP-9 levels are significantly increased in patients with ACI,and are closely related to the degree of carotid atherosclerosis and the nature of plaque.