血清NF-κB、hs-CRP、TNF-α与IL-6在2型糖尿病合并幽门螺杆菌感染者中的表达水平

Expressions of serum NF-κB,hs-CRP,TNF-α and IL-6 in T_(2)DM patients with Hp infection

目的:探讨2型糖尿病合并幽门螺杆菌(Hp)感染者与非Hp感染者对比血清核因子(NF)-κB、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α与白细胞介素(IL)-6的表达的临床意义。方法:选取125例2型糖尿病患者,分为Hp感染组(感染组)和Hp未感染组(对照组),采用酶联免疫吸附试验检测血清NF-κB、hs-CRP、TNF-α与IL-6的表达,比较两组间的差异。结果:感染组血清NF-κB、hs-CRP、TNF-α和IL-6表达水平均显著高于对照组,差异有统计学意义(P<0.01)。感染组中血清NF-κB表达与TNF-α及IL-6的表达呈正相关性(P<0.05)。结论:2型糖尿病患者合并Hp感染可以引起TNF-α、IL-6、hs-CRP活性增强,并且NF-κB对TNF-α和IL-6具有调控作用。

Objective To study the expressions of serum NF-κB,hs-CRP,TNF-α and IL-6 in T_(2)DM patients with Hp infection and clinical significances.Method 125 T_(2)DM patients were selected,and divided into Hp infection group(Hp group)and non Hp infection group(control group)according to whether they were infected with Hp.Enzyme linked immunosorbent assay(ELISA)was used to detect the expressions NF-κB,hs-CRP,TNF-α and IL-6,and compared between two groups.Results Compared with the two groups,expressions of NF-κB,hs-CRP,TNF-α and IL-6 in Hp group were significantly increased than those of control group(P<0.01).In Hp group,the expression of NF-κB were positively correlated with TNF-α and IL-6(P<0.05).Conclusion Hp infection can increase the activity of serum of NF-κB,hs-CRP,TNF-α and IL-6 in T2DM patients,and NF-κB regulates the expressions of TNF-α and IL-6.