二甲双胍联合利拉鲁肽对老年2型糖尿病炎症和肠道菌群失衡的临床治疗效果

Clinical effect of metformin combined with liraglutide on inflammation and intestinal microflora imbalance in elderly type 2 diabetes mellitus patrents

目的:探讨在老年2型糖尿病(T2DM)治疗中应用二甲双胍和利拉鲁肽的效果及对患者炎症和肠道菌群失衡的影响。方法:回顾性分析66例老年T2DM患者临床资料,按抽签随机法分为观察组和对照组各33例。对照组以二甲双胍单药治疗,观察组则采用二甲双胍与利拉鲁肽联合用药方案治疗,比较不同方案治疗差异及相关指标变化。结果:治疗前两组血糖、微炎症及肠道菌群情况比较差异无统计学意义(P>0.05);治疗后观察组糖化血红蛋白(HbA1c)、餐后2 h血糖(2 hBG)、空腹血糖(FBG)、白细胞介素(IL)-6及肿瘤坏死因子(TNF)-α水平均低于对照组,双歧杆菌、乳酸杆菌和拟杆菌数量均多于对照组,差异有统计学意义(P<0.05)。结论:在老年T2DM治疗中联合二甲双胍和利拉鲁肽可以改善机体微炎症状态,降低血糖并增加有益菌群数量。

Objective To investigate the effect of metformin and liraglutide in the treatment of elderly type 2 diabetes mellitus(T2DM)and its effects on inflammation and intestinal microflora imbalance.Method The clinical data of 66 elderly patients with T2DM admitted to hospital from October 2019 to June 2021 were retrospectively analyzed.The patients were randomly divided into control and observation groups,33 cases in each group,by drawing lots.The control group was treated with metformin alone,while the observation group was treated with metformin and liraglutide combined regimen.The differences between different regimen and the changes of related indexes were compared.Results There were no significant differences in blood glucose,microinflammation and intestinal flora between the two groups before treatment(P>0.05).After treatment,the levels of HbA1c,2 hBG,FBG,IL-6 and TNF-α in the observation group were lower than those of the control group,while the numbers of Bifidobacterium,Lactobacillus and Bacteroidetes in the observation group were higher than those of the control group(P<0.05).Conclusion The combination of metformin and liraglutide in the treatment of elderly T2DM could improve the microinflammatory state,reduce blood glucose and increase the number of beneficial bacteria.