膝骨关节炎患者血液及关节积液中丙二醛、超氧化物歧化酶、一氧化氮分型研究

The relationship between syndrome typing and Meridian musculatures classification of knee bi-disease with the content of MDA, SOD and NO in knee effusion and serum

目的:探讨膝骨关节炎患者血液及关节积液中丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)含量与经筋分型和证候分型相关性。方法:选取伴关节积液的膝骨性关节炎(KOA)患者135例,按经筋分型标准分为足阳明经筋组、足太阳经筋组、足少阳经筋组、足三阴经筋组;按证候分型标准分为风湿热痹组、风寒湿痹组、瘀血痹阻组、肝肾亏虚组。治疗开始前测定血液和关节积液内MDA、SOD、NO含量。结果:各证型组治疗开始前血液和关节积液内MDA、SOD、NO含量差异有统计学意义(P<0.05)。结论:膝痹病血液及关节积液中MDA、SOD、NO含量可以为经筋分型和证候分型提供参考依据。

Objective To explore the correlation among TCM syndrome classification, Meridian Musculatures Classification and the content of malondialdehyde(MDA), superoxide dismutase(SOD) and nitric oxide(NO) in KOA patient′ s knee joint effusion and serum.Method 135 patients with osteoarthritis of the knee with joint effusion were selected and divided into group of Yang-Ming Meridian Musculatures, Tai-Yang Meridian Musculatures, Shao-Yang Meridian Musculatures, and San-Yin Meridian Musculatures according to standard of TCM Musculatures classification. On this basis, those patients were divided into group of rheumatic heat arthralgia syndrome, wind cold damp arthralgia syndrome, liver-kidney deficiency syndrome, and blood stasis and arthralgia syndrome according to standard of TCM syndrome types. The contents of MDA, SOD and NO in patient′ s knee joint effusion and serum were measured before treatment.Results Comparison of the contents of MDA, SOD and NO in patient′ s knee joint effusion and serum in each Meridian Musculatures and syndrome group showed statistically significant difference(P<0.05).Conclusion The contents of MDA, SOD and NO in patient′ s knee joint effusion and serum of patients with knee osteoarthritis can be used as the reference basis for the macroscopic syndrome differentiation of TCM and Meridian Musculatures Classification.