血糖调节激素与胃癌关系的研究进展

Research progress on relation between blood glucose regulating hormones and gastric cancer

目的了解血糖调节激素与胃癌的关系,期望能为胃癌诊断和治疗提供新的思路。方法通过查阅国内外的相关文献,归纳并总结有关血糖调节激素与胃癌关系研究的最新进展情况。结果胰岛素、胰高血糖素、肾上腺素、生长激素等血糖调节激素均在胃癌的发生及发展中起到了促进作用,而糖皮质激素和生长抑素分别是维持胃稳态和抑制胃癌细胞增殖的保护性激素。结论血糖调节激素对胃癌的诊断和治疗有一定的价值,但血糖调节激素之间的相互作用、糖代谢在胃癌生物学行为中的作用、血糖调节激素对癌基因启动的影响等具体的机制仍不明确,需要进一步进行前瞻性的临床对照研究。

Objective To understand the relation between blood glucose regulating hormones and gastric cancer,so as to provide some new ideas for diagnosis and treatment of gastric cancer.Method By reviewing and screening relevant domestic and foreign literatures,the latest researches on the relation between blood glucose regulating hormones and gastric cancer were summarized.Results The insulin,glucagon,adrenaline,growth hormone,and the other blood glucose regulating hormones all played the roles in promoting the occurrence and development of gastric cancer.However,glucocorticoids and somatostatin were protective hormones that maintained gastric homeostasis and inhibited the proliferation of gastric cancer cells.Conclusion Blood glucose regulating hormones play some roles in diagnosis and treatment of gastric cancer,but specific mechanisms such as interaction between blood glucose regulating hormones,role of glucose metabolism in biological behavior of gastric cancer,and effect of blood glucose regulating hormones on oncogene initiation are unclear,so prospective clinical control studies still need to be studied.