摘要
目的:观察清肺健脾方治疗中重度痤疮瘢痕的临床疗效。方法:选取痤疮患者120例,按随机数字表法分为对照组及观察组各60例。对照组给予常规西药治疗,观察组在对照组基础上联用清肺健脾方治疗,疗程6周。比较2组治疗前后中医证候积分、皮损积分、痤疮继发瘢痕权重评分(ECCA)、皮肤病生活质量指数(DLQI)及血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。比较2组总有效率及不良反应发生率。结果:观察组总有效率为96.67%,高于对照组70.00%,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分、皮损积分、ECCA及DLQI评分均较治疗前显著下降(P<0.05),且观察组下降幅度大于对照组(P<0.05)。治疗后,2组血清IL-1、IL-6、TNF-α水平均较治疗前明显降低(P<0.05),且观察组炎症指标均低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:清肺健脾方治疗中重度痤疮瘢痕临床疗效显著,能够减轻皮损和痤疮瘢痕形成,提高患者生活质量,其作用机制可能与改善血清IL-1、IL-6、TNF-α水平有关。
Objective:To observe the clinical effect of Qingfei Jianpi prescription for moderate to severe acne scar.Methods:A total of 120 cases of patients with acne scar were selected and divided into the control group and the observation group according to the random number table method,with 60 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with Qingfei Jianpi prescription based on the treatment of the control group.Both groups were treated for six weeks.Chinese medicine syndrome scores,skin lesion scores,scores of Echelle d’evaluation clinique des cicatrices d’acne(ECCA)and Dermatology Life Quality Index(DLQI)and the levels of interleukin-1(IL-1),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in serum were compared between the two groups before and after treatment.The total effective rate and incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 96.67%in the observation group,higher than that of 70.00%in the control group,the differences being significant(P<0.05).After treatment,scores of Chinese medicine syndrome,skin lesions,ECCA and DLQI in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the decrease in the observation group was larger than that in the control group(P<0.05).After treatment,levels of IL-1,IL-6 and TNF-αin the two groups were significantly decreased when compared with those before treatment(P<0.05),and the inflammatory indexes in the observation group were lower than those in the control group(P<0.05).There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P>0.05).Conclusion:Qingfei Jianpi prescription has a significant clinical effect in the treatment of moderate to severe acne scar.It can reduce the formation of skin lesions and acne scars and improve the quality of life of patients.Its mechanism may be related to improving the levels of IL-1,IL-6 and TNF-αin serum.
作者
胡艳阁
田分
房凤霞
邵雅静
王丽
HU Yange;TIAN Fen;FANG Fengxia;SHAO Yajing;WANG Li
出处
《新中医》
CAS
2022年第11期158-161,共4页
New Chinese Medicine
基金
河南省中医药科学研究专项课题(20-21ZY2053)。