参芪薏苡仁粥对氟尿嘧啶化疗后大鼠脾气虚症状和体质量的影响

Effects of Shen Qi Yi Yi Ren Zhou medicated porridge on spleen qi deficiency and body weight of rats after fluorouracil chemotherapy

目的探讨参芪薏苡仁粥对化疗后脾气虚大鼠脾气虚症状和体质量的影响。方法建立化疗后脾气虚大鼠模型,24只大鼠随机分为空白组、药膳组、模型组,每组8只。模型组及药膳组给予5-氟尿嘧啶(5-Fu)制作脾气虚大鼠模型。空白组和模型组使用0.9%生理盐水灌胃,药膳组给予参芪薏苡仁粥灌胃,干预15 d。实验期间观测各组大鼠脾气虚症状和体质量变化。结果重复测量分析结果显示,各组间大鼠脾气虚证候评分和体质量变化差异具有统计学意义(P<0.05),且各组大鼠脾气虚症状评分和体质量随时间变化的趋势存在差异(P<0.05)。结论参芪薏苡仁粥能够明显改善化疗后大鼠脾气虚症状,促进大鼠化疗后体质量恢复。

Objective To observe the influence of Shen Qi Yi Yi Ren Zhou on the body weight and spleen qi deficiency syndrome in spleen qi deficiency model rats.Methods Twenty-four SPF Wistar rats were randomly assigned to three different study groups which included model group,intervention group and control group,and eight rats were included in each group.Rats in model group and intervention group were injected with 5-FU to reproduce the model of chemotherapy-induced spleen qi deficiency.During the 15 days of the study,rats in intervention group were treated with Shen Qi Yi Yi Ren Zhou 10 mL/kg,the model group and control group were treated with rice porridge at the same dose.Body weight and spleen qi deficiency syndrome were collected on the last day of experiment.Results The results of repeated measure analysis showed that there were significant differences in spleen qi deficiency syndrome score and body weight among the groups(P<0.05),and interaction between time and intervention had significant effect(P<0.05).Conclusion Shen Qi Yi Yi Ren Zhou can significantly improve the symptoms of spleen qi deficiency and promote the weight recovery of rats after chemotherapy.