小儿金翘颗粒联合西医常规治疗小儿肺炎风热犯肺证的临床研究

Clinical study on Xiaoer Jinqiao Granules combined with conventional therapy of Western medicine in treating infantile pneumonia complicated with the syndrome of wind-heat invading lung

目的观察小儿金翘颗粒联合西医常规治疗小儿肺炎风热犯肺证的临床疗效。方法将106例小儿肺炎风热犯肺证患儿随机分为2组,对照组53例予西医常规治疗,治疗组53例在对照组基础上加小儿金翘颗粒治疗。2组均治疗7 d统计疗效,比较2组发热、咽痛、咳嗽消失时间,比较2组治疗前后炎症因子[包括白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)及T淋巴细胞亚群(包括CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))]水平变化情况,比较2组治疗期间不良反应发生情况。结果治疗组总有效率98.11%(52/53),不良反应总发生率7.55%(4/53),对照组总有效率83.02%(44/53),不良反应总发生率7.55%(4/53),治疗组总有效率高于对照组(P<0.05),但2组不良反应总发生率比较差异无统计学意义(P>0.05)。治疗组发热、咽痛、咳嗽消失时间均短于对照组(P<0.05)。与本组治疗前比较,2组治疗后炎症因子IL-6、TNF-α水平均降低(P<0.05),且治疗组治疗后IL-6、TNF-α水平均低于对照组(P<0.05)。与本组治疗前比较,2组治疗后T淋巴细胞亚群CD4^(+)、CD4^(+)/CD8^(+)水平均升高(P<0.05),CD8^(+)水平均降低(P<0.05),且治疗组治疗CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组(P<0.05),CD8^(+)水平低于对照组(P<0.05)。结论小儿金翘颗粒联合西医常规治疗小儿肺炎风热犯肺证临床疗效确切,可明显促进患者临床症状消失,抑制炎性反应,调节免疫功能,且安全性高,有利于小儿肺炎病情康复。

Objective To observe the clinical efficacy of Xiaoer Jinqiao Granules combined with traditional therapy of in treating infantile pneumonia complicated with the syndrome of wind-heat invading lung.Methods A total of 106 patients with infantile pneumonia complicated with syndrome of wind-heat invading lung randomly divided into two groups,53 patients in the the control group were subject to conventional therapy of Western medicine,and 53 patients in the treatment group was treated with Xiaoer Jinqiao Granules on the basis of the control group.The two groups of children were treated for 7 days,and the then clinical efficacies on patients in two groups were subject to statistic analysis;and the time of disappearance of symptoms involving the fever,sore throat and cough as well as changes in inflammatory factors involving Interleukin-6[IL-6],tumor necrosis factorα[TNF-α]and T lymphocyte subsets(including CD4^(+),CD8^(+)and CD4^(+)/CD8^(+))before and after treatment of patients in two groups were compared;the adverse reactions of patients two groups attacking during treatment were compared,and the difference in the total incidence rate of adverse reactions between two groups weren’t statistically significant(P>0.05).The disappearance time of fever,sore throat and cough of the treatment group was shorter than such indices in the control group(P>0.05).The level of both inflammatory factors IL-6 and TNF-αof two groups after treatment decreased when compared(P<0.05),and the level of both inflammatory factors IL-6 and TNF-αof the treatment was lower than such index of the control group(P<0.05).The level of CD4^(+)and CD4^(+)/CD8^(+)of T lymphocyte subsets in two groups after treatment were higher than those indices in respective group before treatment(P<0.05),and the level of CD8^(+)in both the treatment group and control group was lowered.The level of CD4^(+)and CD4^(+)/CD8^(+)in the treatment group were higher than such indices of the control group(P<0.05),and the level of CD8^(+)in the treatment group was lower than such index of the control group(P<0.05).Results The overall response rate and total incidence rate of adverse reactions of the treatment group after treatment was 98.11%(52/53)and 7.55(4/53),and such indices of the treatment group was 83.02%(44/53)and 7.55(4/53),respectively;and the overall response rate of the treatment group was higher than such index of the control group(P<0.05).Conclusion The Xiaoer Jinqiao Granules combined with conventional therapy of Western medicine honor definite efficacies in treating infantile pneumonia,and can significantly improve the treatment efficacy,and can obviously promote the disappearance of clinical symptoms,inhibit inflammatory reaction and regulate immune function with high safety profile,making for the condition rehabilitation of infantile pneumonia.