2型糖尿病患者血尿酸水平变化与检验价值分析

Analysis of the changes of serum uric acid level in patients with type 2 diabetes mellitus and its testing value

目的分析2型糖尿病患者血尿酸水平变化与检验价值。方法选取100例2型糖尿病患者设为观察组,另抽取同期于健康体检中心体检为健康的100例体检人员设为对照组。两组均进行血尿酸及实验室指标测试。对比两组血尿酸水平、高尿酸血症发生情况,观察组高血尿酸与正常血尿酸患者的实验室指标及并发症发生情况。结果观察组血尿酸(480.45±60.21)μmol/L显著高于对照组的(393.11±38.93)μmol/L,差异有统计学意义(P<0.05)。观察组高尿酸血症发生率为36.00%高于对照组的7.00%,差异有统计学意义(P<0.05)。观察组高血尿酸患者肌酐、总胆固醇、甘油三酯分别为(154.34±20.14)μmol/L、(6.13±1.14)mmol/L、(4.04±0.77)mmol/L,均高于正常血尿酸患者的(102.14±14.52)μmol/L、(4.56±1.02)mmol/L、(2.53±0.52)mmol/L,差异有统计学意义(P<0.05)。观察组高血尿酸患者并发症发生率88.89%高于正常血尿酸患者的46.88%,差异有统计学意义(P<0.05)。结论2型糖尿病血尿酸升高的几率较健康人群高,而血尿酸升高增加了动脉粥样硬化的风险,因此2型糖尿病患者在控制血糖、血脂的同时,还需要加强血尿酸控制,减少并发症的出现。

Objective To analyze the changes of serum uric acid level in patients with type 2 diabetes mellitus and its testing value.Methods 100 patients with type 2 diabetes mellitus were selected as the observation group,and another 100 healthy individuals who underwent physical examination during the same period were selected as the control group.Both groups were tested for serum uric acid and laboratory indicators.Comparison was made on serum uric acid level and occurrence of hyperuricemia between the two groups,as well as the laboratory indexes and complications between patients with hyperuricemia and patients with normal serum uric acid in the observation group.Results The serum uric acid(480.45±60.21)μmol/L in the observation group was significantly higher than(393.11±38.93)μmol/L in the control group,and the difference was statistically significant(P<0.05).The incidence of hyperuricemia 36.00%in the observation group was higher than 7.00%in the control group,and the difference was statistically significant(P<0.05).In the observation group,the creatinine,total cholesterol and triglyceride in patients with hyperuricemia were(154.34±20.14)μmol/L,(6.13±1.14)mmol/L,and(4.04±0.77)mmol/L,which were higher than(102.14±14.52)μmol/L,(4.56±1.02)mmol/L,and(2.53±0.52)mmol/L of patients with normal serum uric acid,and the differences were statistically significant(P<0.05).In the observation group,the complication rate of patients with hyperuricemia was 88.89%,which was higher than 46.88%of patients with normal serum uric acid,and the difference was statistically significant(P<0.05).Conclusion Patients with type 2 diabetes melliltus have a higher chance of elevated blood uric acid than healthy people,and elevated blood uric acid increases the risk of atherosclerosis.Therefore,patients with type 2 diabetes mellitus need to strengthen blood uric acid control along with blood glucose and lipid control to reduce the occurrence of complications.